Innovations in phenotyping of mouse models in the German Mouse Clinic
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- 作者：Helmut Fuchs (1)
Valérie Gailus-Durner (1)
Susanne Neschen (1)
Thure Adler (1) (4)
Luciana Caminha Afonso (1)
Juan Antonio Aguilar-Pimentel (5) (6)
Lore Becker (1) (7)
Alexander Bohla (11)
Julia Calzada-Wack (8)
Christian Cohrs (1)
Anna Dewert (1) (2)
Barbara Fridrich (1)
Lillian Garrett (9)
Lisa Glasl (9)
Alexander G?tz (11)
Wolfgang Hans (1)
Sabine M. H?lter (9)
Marion Horsch (1)
Anja Hurt (1)
Eva Janas (8)
Dirk Janik (8)
Melanie Kahle (1)
Martin Kistler (1) (2)
Tanja Klein-Rodewald (8)
Christoph Lengger (1)
Tonia Ludwig (1)
Holger Maier (1)
Susan Marschall (1)
Kateryna Micklich (1)
Gabriele M?ller (1)
Beatrix Naton (1)
Cornelia Prehn (1)
Oliver Puk (9)
Ildikó Rácz (12)
Michael R?? (1)
Birgit Rathkolb (1) (3)
Jan Rozman (1) (2)
Markus Scheerer (1)
Evelyn Schiller (1)
Anja Schrewe (1)
Ralph Steinkamp (1)
Claudia St?ger (1)
Minxuan Sun (9)
Wilfried Szymczak (10)
Irina Treise (1)
Ingrid Liliana Vargas Panesso (1) (7)
Alexandra M. Vernaleken (1) (7)
Monja Willersh?user (1)
Annemarie Wolff-Muscate (9)
Ramona Zeh (1)
Jerzy Adamski (1) (13)
Johannes Beckers (1) (13)
Raffi Bekeredjian (14)
Dirk H. Busch (4)
Oliver Eickelberg (11)
Jack Favor (16)
Jochen Graw (9)
Heinz H?fler (15) (8)
Christoph H?schen (10)
Hugo Katus (14)
Martin Klingenspor (2)
Thomas Klopstock (7)
Frauke Neff (8)
Markus Ollert (5)
Holger Schulz (18)
Tobias St?ger (11)
Eckhard Wolf (3)
Wolfgang Wurst (17) (19) (20) (9)
Ali ?nder Yildirim (11)
Andreas Zimmer (12)
Martin Hrabě de Angelis (1) (13) (21) - 刊名：Mammalian Genome
- 出版年：2012
- 出版时间：10 - October 2012
- 年：2012
- 卷：23
- 期：9
- 页码：611-622
- 全文大小：851KB
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13. Horsch M, Sch?dler S, Gailus-Durner V, Fuchs H, Meyer H, Hrabé de Angelis M, Beckers J (2008) Systematic gene expression profiling of mouse model series reveals coexpressed genes. Proteomics 8(6):1248-256 CrossRef
14. Kemter E, Rathkolb B, Rozman J, Hans W, Schrewe A, Landbrecht C, Klaften M, Ivandic B, Fuchs H, Gailus-Durner V, Klingenspor M, Hrabé de Angelis M, Wolf E, Wanke R, Aigner B (2009) Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am J Physiol Renal Physiol 297(5):F1391–F1398 CrossRef
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Valérie Gailus-Durner (1)
Susanne Neschen (1)
Thure Adler (1) (4)
Luciana Caminha Afonso (1)
Juan Antonio Aguilar-Pimentel (5) (6)
Lore Becker (1) (7)
Alexander Bohla (11)
Julia Calzada-Wack (8)
Christian Cohrs (1)
Anna Dewert (1) (2)
Barbara Fridrich (1)
Lillian Garrett (9)
Lisa Glasl (9)
Alexander G?tz (11)
Wolfgang Hans (1)
Sabine M. H?lter (9)
Marion Horsch (1)
Anja Hurt (1)
Eva Janas (8)
Dirk Janik (8)
Melanie Kahle (1)
Martin Kistler (1) (2)
Tanja Klein-Rodewald (8)
Christoph Lengger (1)
Tonia Ludwig (1)
Holger Maier (1)
Susan Marschall (1)
Kateryna Micklich (1)
Gabriele M?ller (1)
Beatrix Naton (1)
Cornelia Prehn (1)
Oliver Puk (9)
Ildikó Rácz (12)
Michael R?? (1)
Birgit Rathkolb (1) (3)
Jan Rozman (1) (2)
Markus Scheerer (1)
Evelyn Schiller (1)
Anja Schrewe (1)
Ralph Steinkamp (1)
Claudia St?ger (1)
Minxuan Sun (9)
Wilfried Szymczak (10)
Irina Treise (1)
Ingrid Liliana Vargas Panesso (1) (7)
Alexandra M. Vernaleken (1) (7)
Monja Willersh?user (1)
Annemarie Wolff-Muscate (9)
Ramona Zeh (1)
Jerzy Adamski (1) (13)
Johannes Beckers (1) (13)
Raffi Bekeredjian (14)
Dirk H. Busch (4)
Oliver Eickelberg (11)
Jack Favor (16)
Jochen Graw (9)
Heinz H?fler (15) (8)
Christoph H?schen (10)
Hugo Katus (14)
Martin Klingenspor (2)
Thomas Klopstock (7)
Frauke Neff (8)
Markus Ollert (5)
Holger Schulz (18)
Tobias St?ger (11)
Eckhard Wolf (3)
Wolfgang Wurst (17) (19) (20) (9)
Ali ?nder Yildirim (11)
Andreas Zimmer (12)
Martin Hrabě de Angelis (1) (13) (21)
1. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
4. Institute for Medical Microbiology, Immunology, and Hygiene, TUM, Trogerstra?e 30, 81675, Munich, Germany
5. Clinical Research Division of Molecular and Clinical Allergotoxicology, Department of Dermatology and Allergy, TUM, Biedersteiner Stra?e 29, 80802, Munich, Germany
6. Division of Environmental Dermatology and Allergy TUM/Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
7. Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universit?t München, Ziemssenstra?e 1a, 80336, Munich, Germany
11. Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
8. Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
2. Molecular Nutritional Medicine, Else Kr?ner-Fresenius Center, TUM, Gregor-Mendel-Stra?e 2, 85350, Freising-Weihenstephan, Germany
9. Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
12. Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud-Stra?e 25, 53105, Bonn, Germany
3. Chair for Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universit?t München, Feodor Lynen-Stra?e 25, 81377, Munich, Germany
10. Abteilung Medizinische Strahlenphysik und Diagnostik, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
13. Chair of Experimental Genetics, Center of Life and Food Sciences Weihenstephan, TUM, 85350, Freising-Weihenstephan, Germany
14. Division of Cardiology, Department of Medicine III, University of Heidelberg, Otto-Meyerhof-Zentrum, Im Neuenheimer Feld 350, 69120, Heidelberg, Germany
16. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
15. Institute of Pathology, TUM, Ismaningerstra?e 22, 81675, Munich, Germany
18. Institute of Epidemiology 1, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolst?dter Landstra?e 1, 85764, Neuherberg/Munich, Germany
17. Chair of Developmental Genetics, TUM, Am Hochanger 8, 85350, Freising-Weihenstephan, Germany
19. Max-Planck-Institute of Psychiatry, Kraepelinstra?e 2-10, 80804, Munich, Germany
20. Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE) Site Munich, Schillerstra?e 44, 80336, Munich, Germany
21. Member of German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany - ISSN：1432-1777
文摘
Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations (“bottom-up projects- and as a partner and driver in international large-scale biology projects (“top-down projects-. Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs).