Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study

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• 作者：A Willemien Visser (11)
  Andreea Ioan-Facsinay (11)
  Ren茅e Mutsert de (12)
  Ralph L Widya (13)
  Marieke Loef (11)
  Albert de Roos (13)
  Saskia le Cessie (12)
  Martin den Heijer (12) (14)
  Frits R Rosendaal (12)
  Margreet Kloppenburg (11) (12)
  
• 刊名：Arthritis Research & Therapy
• 出版年：2014
• 出版时间：February 2014
• 年：2014
• 卷：16
• 期：1
• 全文大小：
• 作者单位：A Willemien Visser (11)
  Andreea Ioan-Facsinay (11)
  Ren茅e Mutsert de (12)
  Ralph L Widya (13)
  Marieke Loef (11)
  Albert de Roos (13)
  Saskia le Cessie (12)
  Martin den Heijer (12) (14)
  Frits R Rosendaal (12)
  Margreet Kloppenburg (11) (12)
  
  11. Department of Rheumatology, C1-R, Leiden University Medical Center, P.O. Box 9600, 2300, RC, Leiden, the Netherlands
  12. Department of Clinical Epidemiology, C7-P, Leiden University Medical Center, Box 9600, 2300, RC, Leiden, the Netherlands
  13. Department of Radiology, C2-S, Leiden University Medical Center, P.O. Box 9600, 2300, RC, Leiden, the Netherlands
  14. Department of Endocrinology, Vrije Universiteit Medical Center, P.O. Box 7057, 1007, MB, Amsterdam, the Netherlands
  
• ISSN：1478-6354

文摘

Introduction Obesity, usually characterized by the body mass index (BMI), is a risk factor for hand osteoarthritis (OA). We investigated whether adipose tissue and abdominal fat distribution are associated with hand OA. Methods The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45 to 65 years, including 5315 participants (53% women, median BMI 29.9 kg/m2). Fat percentage and fat mass (FM) (kg) were estimated using bioelectrical impedance analysis. The waist-to-hip ratio (WHR) was calculated. In 1721 participants, visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (cm2) were assessed using abdominal MR imaging. Hand OA was defined according to the ACR criteria. Odds ratios (OR) with 95% confidence intervals (CI) were calculated for the association of fat percentage, FM, WHR, VAT and SAT with hand OA using logistic regression analyses per standard deviation, stratified by sex and adjusted for age. Results Hand OA was present in 8% of men and 20% of women. Fat percentage was associated with hand OA in men (OR 1.34 (95%鈥塁I 1.11 to 1.61)) and women (OR 1.26 (1.05 to 1.51)), as was FM. WHR was associated with hand OA in men (OR 1.45 (1.13 to 1.85)), and to a lesser extent in women (OR 1.17 (1.00 to 1.36)). Subgroup analysis revealed that VAT was associated with hand OA in men (OR1.33 (1.01 to 1.75)). This association increased after additional adjustment for FM (OR 1.51 (1.13 to 2.03)). Conclusions Fat percentage, FM and WHR were associated with hand OA. VAT was associated with hand OA in men, suggesting involvement of visceral fat in hand OA.