Safety and tolerability of intranasal cocaine during phendimetrazine maintenance

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• 作者：William W. Stoops ; Justin C. Strickland ; Lon R. Hays…
• 刊名：Psychopharmacology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：233
• 期：11
• 页码：2055-2063
• 全文大小：450 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072
• 卷排序：233

文摘

RationalePhendimetrazine appears to have limited abuse potential and reduces cocaine self-administration in preclinical studies. No human studies have evaluated the safety and tolerability of cocaine in combination with phendimetrazine, which is a necessary next step in evaluating the efficacy of phendimetrazine for treating cocaine use disorder.