Shared and Distinct Genetic Influences Among Different Measures of Pulmonary Function

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• 作者：Terrie Vasilopoulos (1)
  Michael D. Grant (2)
  Carol E. Franz (3)
  Matthew S. Panizzon (3)
  Hong Xian (4) (5)
  Rosemary Toomey (2)
  Michael J. Lyons (2)
  William S. Kremen (3) (6)
  Kristen C. Jacobson (1)
  
• 关键词：Lung ; Heritability ; Twins ; Genes ; Middle ; age
• 刊名：Behavior Genetics
• 出版年：2013
• 出版时间：March 2013
• 年：2013
• 卷：43
• 期：2
• 页码：141-150
• 全文大小：291KB
• 参考文献：1. Aldrich T, Arora N, Rochester D (1982) The influence of airway obstruction and respiratory muscle strength on maximal voluntary ventilation in lung disease. Am Rev Respir Dis 126(2):195
  2. Balfe DL, Lewis M, Mohsenifar Z (2002) Grading the severity of obstruction in the presence of a restrictive ventilatory defect. Chest 122(4):1365-369 ss="external" href="http://dx.doi.org/10.1378/chest.122.4.1365">CrossRef
  3. Barreiro TJ, Perillo I (2004) An approach to interpreting spirometry. Am Fam Physician 69(5):1107-116
  4. Bass H (1973) The flow volume loop: normal standards and abnormalities in chronic obstructive pulmonary disease. Chest 63(2):171-76 ss="external" href="http://dx.doi.org/10.1378/chest.63.2.171">CrossRef
  5. Boomsma D, Busjahn A, Peltonen L (2002) Classical twin studies and beyond. Nat Rev Genet 3(11):872-82 ss="external" href="http://dx.doi.org/10.1038/nrg932">CrossRef
  6. Boren HG, Kory RC, Syner JC (1966) The veterans administration-army cooperative study of pulmonary function. II The lung volume and its subdivisions in normal men. Am J Med 41(1):96-14 ss="external" href="http://dx.doi.org/10.1016/0002-9343(66)90008-8">CrossRef
  7. Center for Disease Control and Prevention (2003) Public health and aging: trends in aging—United States and worldwide. MMWR CDC Surveill Summ 52:101-06
  8. Chatterjee S, Das N (1995) Lung function in Indian twin children: comparison of genetic versus environmental influence. Ann Hum Biol 22(4):289-03 ss="external" href="http://dx.doi.org/10.1080/03014469500003962">CrossRef
  9. Chen Y (1999) Genetics and pulmonary medicine. 10: genetic epidemiology of pulmonary function. Thorax 54(9):818 ss="external" href="http://dx.doi.org/10.1136/thx.54.9.818">CrossRef
  10. Chyou PH, White LR, Yano K, Sharp DS, Burchfiel CM, Chen R, Rodriguez BL, Curb JD (1996) Pulmonary function measures as predictors and correlates of cognitive functioning in later life. Am J Epidemiol 143(8):750-56 ss="external" href="http://dx.doi.org/10.1093/oxfordjournals.aje.a008812">CrossRef
  11. Eisen S, True W, Goldberg J, Henderson W, Robinette CD (1987) The Vietnam Era Twin (VET) Registry—method of construction. Acta Genet Med Gemellol 36(1):61-6
  12. Gibson P, Simpson J (2009) The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax 64(8):728-35 ss="external" href="http://dx.doi.org/10.1136/thx.2008.108027">CrossRef
  13. Henderson WG, Eisen S, Goldberg J, True WR, Barnes JE, Vitek ME (1990) The Vietnam Era Twin Registry: a resource for medical research. Public Health Rep 105(4):368-73
  14. Hukkinen M, Kaprio J, Broms U, Viljanen A, Kotz D, Rantanen T, Korhonen T (2011) Heritability of lung function: a twin study among never-smoking elderly women. Twin Res Hum Genet 14(5):401 ss="external" href="http://dx.doi.org/10.1375/twin.14.5.401">CrossRef
  15. Ingebrigtsen TS, Thomsen SF, van der Sluis S, Miller M, Christensen K, Sigsgaard T, Backer V (2011) Genetic influences on pulmonary function: a large sample twin study. Lung Epub had a print
  16. Kaseda S, Aoki T, Hangai N, Shimizu K (2000) Better pulmonary function and prognosis with video-assisted thoracic surgery than with thoracotomy. Ann Thorac Surg 70(5):1644-646 ss="external" href="http://dx.doi.org/10.1016/S0003-4975(00)01909-3">CrossRef
  17. Knudson RJ, Slatin R, Lebowitz M, Burrows B (1976) The maximal expiratory flow-volume curve. Normal standards, variability, and effects of age. Am Rev Respir Dis 113(5):587
  18. Kremen W, Thompson-Brenner H, Leung Y, Grant M, Franz C, Eisen S, Jacobson K, Boake C, Lyons M (2006) Genes, environment, and time: the Vietnam Era Twin study of Aging (VETSA). Twin Res Hum Genet 9(6):1009-022 ss="external" href="http://dx.doi.org/10.1375/twin.9.6.1009">CrossRef
  19. Lebecque P, Kiakulanda P, Coates A (1993) Spirometry in the asthmatic child: is FEF25-5 a more sensitive test than FEV1/FVC? Pediatr Pulmonol 16(1):19-2 ss="external" href="http://dx.doi.org/10.1002/ppul.1950160105">CrossRef
  20. Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC (2002) Chronic obstructive pulmonary disease surveillance-United States, 1971-000. Respir care 47(10):1184-199
  21. Marcus EB, Curb JD, MacLean CJ, Reed DM, Yano K (1989) Pulmonary function as a predictor of coronary heart disease. Am J Epidemiol 129(1):97-04
  22. McClearn GE, Svartengren M, Pedersen NL, Heller DA, Plomin R (1994) Genetic and environmental influences on pulmonary function in aging Swedish twins. J Gerontol 49(6):M264 ss="external" href="http://dx.doi.org/10.1093/geronj/49.6.M264">CrossRef
  23. McFadden E, Linden DA (1972) A reduction in maximum mid-expiratory flow rate: a spirographic manifestation of small airway disease. Am J Med 52(6):725-37 ss="external" href="http://dx.doi.org/10.1016/0002-9343(72)90078-2">CrossRef
  24. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, Van Der Grinten C, Gustafsson P (2005) Standardisation of spirometry. Eur Respir J 26(2):319-38 ss="external" href="http://dx.doi.org/10.1183/09031936.05.00034805">CrossRef
  25. National Center for Disease Statistics (2003) U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. Hyattsville, MD
  26. Neale MC, Boker S, Xie G, Maes HH (2004) Mx: statistical modeling. In: Virginia Commonwealth University, Richmond
  27. Pathan SS, Gottesman RF, Mosley TH, Knopman DS, Sharrett AR, Alonso A (2011) Association of lung function with cognitive decline and dementia: the atherosclerosis risk in communities (ARIC) study. Eur J Neurol 18(6):888-98 ss="external" href="http://dx.doi.org/10.1111/j.1468-1331.2010.03340.x">CrossRef
  28. Pauwels RA (2000) National and international guidelines for COPD—the need for evidence. Chest 117(2):20-2 ss="external" href="http://dx.doi.org/10.1378/chest.117.2_suppl.20S">CrossRef
  29. Pellegrino R, Viegi G, Brusasco V, Crapo R, Burgos F, Casaburi R, Coates A, van der Grinten C, Gustafsson P, Hankinson J (2005) Interpretative strategies for lung function tests. Eur Respir J 26(5):948-68 ss="external" href="http://dx.doi.org/10.1183/09031936.05.00035205">CrossRef
  30. Plomin R, DeFries J, McClearn G, McGuffin P (2001) Behavior genetics. Worth, New York
  31. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: gold executive summary. Am J Respir Crit Care Med 176(6):532 ss="external" href="http://dx.doi.org/10.1164/rccm.200703-456SO">CrossRef
  32. Schünemann HJ, Dorn J, Grant BJB, Winkelstein W, Trevisan M (2000) Pulmonary function is a long-term predictor of mortality in the general population. Chest 118(3):656-64 ss="external" href="http://dx.doi.org/10.1378/chest.118.3.656">CrossRef
  33. Simon, Chinchilli VM, Phillips BR, Sorkness CA, Lemanske RF Jr, Szefler SJ, Taussig L, Bacharier LB, Morgan W (2010) Forced expiratory flow between 25 and 75?% of vital capacity and FEV1/forced vital capacity ratio in relation to clinical and physiological parameters in asthmatic children with normal FEV1 values. J Allergy Clin Immunol 126(3):527-34 e528 ss="external" href="http://dx.doi.org/10.1016/j.jaci.2010.05.016">CrossRef
  34. So HC, Gui AHS, Cherny SS, Sham PC (2011) Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genet Epidemiol 35(5):310-17 ss="external" href="http://dx.doi.org/10.1002/gepi.20579">CrossRef
  35. Soler Artigas M, Wain LV, Tobin MD (2012) Genome-wide association studies in lung disease. Thorax 67(3):271-73 ss="external" href="http://dx.doi.org/10.1136/thoraxjnl-2011-200724">CrossRef
  36. Tzortzaki EG, Proklou A, Siafakas NM (2011) Asthma in the elderly: can we distinguish it from COPD? J Allergy EPub had a print
  37. Vasilopoulos T, Mack HA, McClearn GE, Berg S, Johansson B, Vogler GP (2010) Stability of genetic influences on pulmonary function in a longitudinal study of octogenarian twins. Am J Hum Biol 22(3):375-77 ss="external" href="http://dx.doi.org/10.1002/ajhb.21003">CrossRef
  38. Wilk JB, Djousse L, Arnett DK, Rich SS, Province MA, Hunt SC, Crapo RO, Higgins M, Myers RH (2000) Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study. Genet Epidemiol 19(1):81-4 ss="external" href="http://dx.doi.org/10.1002/1098-2272(200007)19:1<81::AID-GEPI6>3.0.CO;2-8">CrossRef
  39. Wilk JB, DeStefano AL, Joost O, Myers RH, Cupples LA, Slater K, Atwood LD, Heard-Costa NL, Herbert A, O’Connor GT (2003) Linkage and association with pulmonary function measures on chromosome 6q27 in the framingham heart study. Hum Mol Genet 12(21):2745 ss="external" href="http://dx.doi.org/10.1093/hmg/ddg311">CrossRef
  40. Wu T, Boezen H, Postma D, Los H, Postmus P, Snieder H, Boomsma D (2010) Genetic and environmental influences on objective intermediate asthma phenotypes in Dutch twins. Eur Respir J 36(2):261-68 ss="external" href="http://dx.doi.org/10.1183/09031936.00123909">CrossRef
  
• 作者单位：Terrie Vasilopoulos (1)
  Michael D. Grant (2)
  Carol E. Franz (3)
  Matthew S. Panizzon (3)
  Hong Xian (4) (5)
  Rosemary Toomey (2)
  Michael J. Lyons (2)
  William S. Kremen (3) (6)
  Kristen C. Jacobson (1)
  
  1. Department of Psychiatry & Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue, MC 3077 CNPRU, Chicago, IL, 60637, USA
  2. Department of Psychology, Boston University, Boston, MA, USA
  3. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
  4. Department of Biostatistics, Saint Louis University, St. Louis, MO, USA
  5. VA St. Louis Healthcare System, St. Louis, MO, USA
  6. Center for Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, USA
  
• ISSN：1573-3297

文摘

We examined shared and distinct genetic influences among standard measures of pulmonary functions: ratio of forced expiratory volume at 1?s to forced vital capacity (FEV1/FVC) and percent predicted values for forced expiratory volume at 1?s (FEV1%p), forced expiratory flow (FEFmax%p), and maximal voluntary ventilation (MVV%p) in 978-,048 middle-aged (mean age?=?55?years) male–male twins from the Vietnam Era Twin Study of Aging. A common latent factor (h2?=?0.30) accounted for the correlations among these measures. This factor accounted for 54-1?% of the heritability of FEV1%p, FEFmax%p and MVV%p, but only explained 16?% of the heritability of FEV1/FVC. The remaining heritability of FEV1/FVC was explained by genetic influences independent of the common factor. Our findings suggest that while a common latent phenotype accounts for the relationships among different pulmonary function measures, the majority of genetic influences underlying FEV1/FVC—an index of pulmonary obstruction—are distinct from those underlying other pulmonary function measures.