Δ9-Tetrahydrocannabinol (THC) enhances lipopolysaccharide-stimulated tissue factor in human monocytes and monocyte-derived microvesicles
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- 作者：Julie C. Williams ; Thomas W. Klein ; Bruce A. Goldberger…
- 关键词：Lipopolysaccharide ; Marijuana ; Monocyte ; Tissue factor ; THC
- 刊名：Journal of Inflammation
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：12
- 期：1
- 全文大小：813 KB
- 刊物主题：Molecular Medicine; Immunology; Pharmacology/Toxicology;
- 出版者：BioMed Central
- ISSN：1476-9255
文摘
Background Immunomodulatory effects in humans of Δ9−Tetrahydrocannabinol (THC), the psychoactive component of marijuana are controversial. Tissue factor (TF), the activator of the extrinsic coagulation cascade, is increased on circulating activated monocytes and is expressed on microvesicles released from activated monocytes during inflammatory conditions, which perpetuate coagulopathies in a number of diseases. In view of the increased medicinal use of marijuana, effects of THC on human monocytes and monocyte-derived microvesicles activated by lipopolysaccharide (LPS) were investigated.