Oral Contraceptive Use and Bone

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• 作者：Shuying Wei (1)
  Tania Winzenberg (1)
  Laura L. Laslett (1)
  Alison Venn (1)
  Graeme Jones (1)
  
• 关键词：Oral contraceptive ; Bone mass ; Fracture ; Bone turnover marker ; Adolescent ; Young adults
• 刊名：Current Osteoporosis Reports
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：9
• 期：1
• 页码：6-11
• 全文大小：120KB
• 参考文献：1. Caliri A, De Filippis L, Bagnato GL, Bagnato GF: Osteoporotic fractures: mortality and quality of life. Panminerva Med 2007, 49:21-7.
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  12. ?-Scholes D, Ichikawa L, LaCroix AZ, et al.: Oral contraceptive use and bone density in adolescent and young adult women. Contraception 2010, 81:35-0. / This study investigated the association between duration of OC use and BMD in both adolescents and young adults, and also examined different dosages of OC in a population-based sample. CrossRef
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• 作者单位：Shuying Wei (1)
  Tania Winzenberg (1)
  Laura L. Laslett (1)
  Alison Venn (1)
  Graeme Jones (1)
  
  1. Menzies Research Institute, University of Tasmania, Private bag 23, Hobart, Tasmania, 7000, Australia
  

文摘

Sex hormones play a key role in bone homeostasis, and oral contraceptive (OC) use may affect bone mass in women. However, the nature of the association between OC use and bone remains controversial. This paper critically reviews studies on OC use and bone published between January 2009 and August 2010. Studies of OC use and bone mass mainly focus on adolescents or young adults and showed mixed results. Weak evidence suggests that OC use has no effect or a beneficial effect on bone mass, except in women commencing OCs shortly after menarche, and a consistently negative effect on bone turnover markers. A limited number of studies have examined the effect of ultra-low-dose OC (20?μg ethinyl estradiol) on bone mass in adolescents or young adults, and present conflicting results. The lack of randomized trials indicates that further high-quality prospective studies are required to investigate the effect of OC use on bone mass, particularly the optimal dose and timing of initiation of OC use in adolescents requiring contraception.