Importance of Wet Packability of Component Particles in Pellet Formation

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• 作者：Srimanta Sarkar (1)
  Tin Wui Wong (2)
  Celine Valeria Liew (1)
  
• 关键词：cross ; linked polyvinyl pyrrolidone ; extrusion ; packing ; spheronization
• 刊名：AAPS PharmSciTech
• 出版年：2013
• 出版时间：September 2013
• 年：2013
• 卷：14
• 期：3
• 页码：1267-1277
• 全文大小：392KB
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• 作者单位：Srimanta Sarkar (1)
  Tin Wui Wong (2)
  Celine Valeria Liew (1)
  
  1. GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive, Singapore, 117543, Singapore
  2. Particle Design Research Group, Faculty of Pharmacy, Non-Destructive Biomedical and Pharmaceutical Research Centre, Universiti Teknologi MARA Malaysia, Puncak Alam, Selangor, 42300, Malaysia
  

文摘

This work explored the importance of packability of component particles in the different wet processing steps of extrusion–spheronization and investigated different processing and formulation approaches for enhancing packing of component particles during extrusion–spheronization to produce spherical pellets with high yield and narrow size distribution. Various cross-linked polyvinyl pyrrolidone (XPVP) and lactose grades with different particle sizes were used as pelletization aid and filler in 1:3 binary powder blends. Loosely packed extrudates obtained from coarse XPVP/lactose blends possessed low cohesive strength and produced irregular shaped pellets with low yield whereas tightly packed, rigid extrudates obtained from XPVP/fine lactose grades possessed high cohesive strength and produced elongated pellets. Adjustment of spheronization tip speed to provide sufficient forces generated by the rotating frictional base plate for facilitating packing by rearrangement of component particles improved pellet quality. Double extrusion, decreasing particle size of the formulation component(s), and/or widening particle size distribution of the powder blend are approaches applicable to improve cohesiveness of moistened mass by closer packing of component particles for production of good quality pellets.