Age exacerbates HIV-associated white matter abnormalities
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- 作者：Talia R. Seider ; Assawin Gongvatana ; Adam J. Woods…
- 关键词：HIV ; Aging ; White matter ; White matter hyperintensities ; Diffusion tensor imaging ; Fractional anisotropy
- 刊名：Journal of NeuroVirology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：2
- 页码：201-212
- 全文大小：1,442 KB
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Assawin Gongvatana (3) (4)
Adam J. Woods (1)
Huaihou Chen (5)
Eric C. Porges (1)
Tiffany Cummings (1) (2)
Stephen Correia (4)
Karen Tashima (6) (7)
Ronald A. Cohen (1) (2)
1. Center for Cognitive Aging and Memory (CAM), Institute on Aging, Department of Aging and Geriatric Research, University of Florida, 2004 Mowry Road, Gainesville, FL, 32610, USA
2. Department of Clinical and Healthy Psychology, University of Florida, Gainesville, FL, 32611, USA
3. Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA
4. Department of Psychiatry and Human Behavior, Brown University, Providence, RI, 02912, USA
5. Department of Biostatistics, University of Florida, Gainesville, FL, 32610, USA
6. Department of Medicine, Brown University, Providence, RI, 02903, USA
7. AIDS Clinical Trial Unit, The Miriam Hospital, Providence, RI, 02903, USA - 刊物主题：Neurosciences; Virology; Infectious Diseases; Immunology; Neurology;
- 出版者：Springer US
- ISSN：1538-2443
文摘
Both HIV disease and advanced age have been associated with alterations to cerebral white matter, as measured with white matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), and more recently with diffusion tensor imaging (DTI). This study investigates the combined effects of age and HIV serostatus on WMH and DTI measures, as well as the relationships between these white matter measures, in 88 HIV seropositive (HIV+) and 49 seronegative (HIV−) individuals aged 23–79 years. A whole-brain volumetric measure of WMH was quantified from FLAIR images using a semi-automated process, while fractional anisotropy (FA) was calculated for 15 regions of a whole-brain white matter skeleton generated using tract-based spatial statistics (TBSS). An age by HIV interaction was found indicating a significant association between WMH and older age in HIV+ participants only. Similarly, significant age by HIV interactions were found indicating stronger associations between older age and decreased FA in the posterior limbs of the internal capsules, cerebral peduncles, and anterior corona radiata in HIV+ vs. HIV− participants. The interactive effects of HIV and age were stronger with respect to whole-brain WMH than for any of the FA measures. Among HIV+ participants, greater WMH and lower anterior corona radiata FA were associated with active hepatitis C virus infection, a history of AIDS, and higher current CD4 cell count. Results indicate that age exacerbates HIV-associated abnormalities of whole-brain WMH and fronto-subcortical white matter integrity.