Establishment of a cervical cancer bio-bank for the Chinese population: from project-based sample collection to routine management
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  • 作者:Ru Yang ; Xiong Li ; Hang Zhou ; Yao Jia ; Jin Zhou…
  • 关键词:Bio ; bank ; Cervical cancer ; China
  • 刊名:Archives of Gynecology and Obstetrics
  • 出版年:2015
  • 出版时间:August 2015
  • 年:2015
  • 卷:292
  • 期:2
  • 页码:399-404
  • 全文大小:381 KB
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  • 作者单位:Ru Yang (1) (2)
    Xiong Li (1)
    Hang Zhou (1) (3)
    Yao Jia (1)
    Jin Zhou (1)
    Kecheng Huang (1)
    Fangxu Tang (1)
    Ting Hu (1)
    Jian Shen (1)
    Zhilan Chen (1)
    Shaoshuai Wang (1)
    Haiying Sun (1)
    Lili Guo (1)
    Lin Wang (1)
    Hui Wang (1)
    Ding Ma (1)
    Shuang Li (1)

    1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People鈥檚 Republic of China
    2. Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, People鈥檚 Republic of China
    3. Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
  • 刊物类别:Medicine
  • 刊物主题:Medicine & Public Health
    Gynecology
    Obstetrics and Perinatology
    Endocrinology
    Human Genetics
  • 出版者:Springer Berlin / Heidelberg
  • ISSN:1432-0711
文摘
Purpose There is an increasing need for the establishment of a cervical cancer bio-bank that will facilitate both clinical and basic research. Methods The cervical cancer bio-bank was first established in January 1999 and included two stages. First, a GWAS-based sample collection was conducted with special emphasis on the diagnosis and the retrieval of the corresponding bio-specimens, especially blood samples. Second, clinical data and their corresponding bio-specimens were routinely collected and handled. Notably, these bio-specimens also included samples from Wufeng Tujia Autonomous County, which has the highest incidence of cervical cancer in China. The specimens were collected from patients with cervical cancer and those with cervical intraepithelial neoplasia, while the control samples were collected from normal individuals. Results With special emphasis on clinical data and blood samples for the GWAS analysis, the collection of other bio-specimens was slow, and the pairing of specimens and clinical data was poor during the first stage. However, in the second stage, the pairing of the clinical data and its corresponding bio-specimens improved. At present, the samples procured and preserved in the bio-bank cover most regions of China and different ethnic groups for both the normal controls and cervical cancer patients of different pathological categories. Conclusions This bio-bank of cervical cancer specimens from the Chinese population will greatly promote the studies of cervical cancer in China.

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