SENP2 regulated the stability of β-catenin through WWOX in hepatocellular carcinoma cell

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• 作者：Qing-Feng Jiang (1)
  Yu-Wei Tian (1)
  Quan Shen (1)
  Huan-Zhou Xue (1)
  Ke Li (1)
  
• 关键词：SENP2 ; WWOX ; Hepatocellular carcinoma cell ; SUMOylation
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：35
• 期：10
• 页码：9677-9682
• 全文大小：600 KB
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• 作者单位：Qing-Feng Jiang (1)
  Yu-Wei Tian (1)
  Quan Shen (1)
  Huan-Zhou Xue (1)
  Ke Li (1)
  
  1. Department of Hepatobiliary Surgery, Henan Provincial People’s Hospital, Zhengzhou, 450003, Henan, China
  
• ISSN：1423-0380

文摘

SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activities. The SUMO proteases (SENP) remove SUMO conjugate from proteins, and their expression is deregulated in cancers. SENP2 has been reported to play a critical role in the control of hepatocellular carcinoma (HCC) cell growth by modulating the stability of β-catenin. However, the underlying mechanism remains largely unknown. Here, we show that the WW domain-containing oxidoreductase (WWOX), a novel inhibitor of the Wnt/β-catenin pathway, is required for stabilization of β-catenin regulated by SENP2 in HCC cells. The transcriptional level of WWOX is tightly regulated by SENP2. Moreover, knockdown of WWOX by siRNA attuned SENP2-induced β-catenin degradation and decreased SENP2-mediated HCC cell proliferation arrest. Taken together, our data suggested that WWOX is a key downstream modulator of the SENP2 tumor suppressor function in HCC cell.