Hereditary xanthinuria and urolithiasis in a domestic shorthair cat

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• 作者：E. Furman ; E. H. Hooijberg ; J. Leidinger ; C. Zedinger…
• 关键词：Urine crystals ; Feline lower urinary tract disorders (FLUTD) ; Purine metabolism ; Metabolic disease ; Nephrolithiasis ; Uric acid
• 刊名：Comparative Clinical Pathology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：24
• 期：6
• 页码：1325-1329
• 全文大小：422 KB
• 参考文献：Althof S, Kindler J (2006) Das Harnsediment. Atlas 鈥?Untersuchungstechnik 鈥?Beurteilung, 7th edn. Thieme, Stuttgart, pp 14鈥?0, in German
  Bass M, Howard J, Gerber B, Messmer M (2005) Retrospective study of indications for and outcome of perineal urethrostomy in cats. J Small Anim Pract 46:227鈥?31CrossRef PubMed
  Bradbury MG, Henderson M, Brocklebank JT, Simmonds HA (1995) Acute renal failure due to xanthine stones. Pediatr Nephrol 9:476鈥?77CrossRef PubMed
  Cannon AB, Westropp JL, Ruby AL, Kass PH (2007) Evaluation of trends in urolith composition in cats: 5,230 cases (1985鈥?004). J Am Vet Med Assoc 15:570鈥?76CrossRef
  Corgozinho KB, de Souza HJM, Pereira AN, Belchior C, da Silva MA, Martins MCL, Damico CB (2007) Catheter induced urethral trauma in cats with urethral obstruction. J Fel Med Surg 9:481鈥?86CrossRef
  Eggertsdottir AV, Lund HS, Krontveit R, S酶rum H (2007) Bacteriuria in cats with feline lower urinary tract disease: a clinical study of 134 cases in Norway. J Fel Med Surg 9:458鈥?65CrossRef
  Flegel T, Freistadt R, Haider W (1998) Xanthine urolithiasis in a dachshund. Vet Rec 143:420鈥?23CrossRef PubMed
  Fujiwara Y, Kawakami Y, Shinohara Y, Ichida K (2012) A case of hereditary xanthinuria type 1 accompanied by bilateral renal calculi. Intern Med 51:1879鈥?884CrossRef PubMed
  Gow AG, Fairbanks LD, Simpson JW, Jacinto AML, Ridyard AE (2011) Xanthine urolithiasis in a Cavalier King Charles spaniel. Vet Rec 169:209鈥?10CrossRef PubMed
  Griffin DW, Gregory CR (1992) Prevalence of bacterial urinary tract infection after perineal urethrostomy in cats. J Am Vet Med Assoc 200:681鈥?84PubMed
  Hesse A, Orzekowsky H, Frenk M, Neiger R (2012) Epidemiologische Daten zur Harnsteinerkrankung bei Katzen im Zeitraum 1981鈥?008. Tier盲rztl Prax Kleintiere Heimtiere 40:95鈥?01, in German
  Jacinto AML, Mellanby RJ, Chandler M, Bommer NX, Carruthers H, Fairbanks LD, Gow AG (2013) Urine concentration of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles spaniels. J Small Anim Pract 54:395鈥?98CrossRef PubMed
  Kucera J, Bulkova T, Rychla JP (1997) Bilateral xanthine nephrolithiasis in a dog. J Small Anim Pract 38:302鈥?05CrossRef PubMed
  Ling GV, Ruby AL, Harrold DR, Johnson DL (1991) Xanthine-containing urinary calculi in dogs given allopurinol. J Am Vet Med Assoc 198:1935鈥?940PubMed
  Mestrinho LA, Goncalves T, Parreira PB, Niza MM, Hamaide AJ (2013) Xanthine urolithiasis causing bilateral ureteral obstruction in a 10-month-old cat. J Fel Med and Surg 15:911鈥?16CrossRef
  Osborne CA, Stevens JB (1999) Urine sediment: under the microscope. In: Osborne CA (ed) A clinical guide to compassionate patient care. Bayer Corporation, Leverkusen, pp 125鈥?79
  Osborne CA, Caywood DD, Johnston GR, Polzin DJ, Lulich JP, Kruger JM, Ulrich LK (1996a) Feline perineal urethrostomy: a potential cause of feline lower urinary tract disease. Vet Clin North Am Small Anim Pract 26:535鈥?49CrossRef PubMed
  Osborne CA, Lulich JP, Ulrich LK, Bird KA (1996b) Feline crystalluria. Detection and interpretation. Vet Clin North Am Small Anim Pract 26:369鈥?91CrossRef PubMed
  Osborne CA, Bartges JW, Lulich JP, Ulrich L, Carpenter K, Koehler L (2004) Feline xanthine urolithiasis: a newly recognized cause of urinary tract disease. Proceedings of the ACVIM Forum, Charlotte, NC: pp 781鈥?82
  Osborne CA, Bartages JW, Lulich JP, Albasan H, Weiss C (2010) Canine purine urolithiasis: causes, detection, management and prevention. In: Hands MS, Thatcher CD, Remillard RL et al (eds) Small animal clinical nutrition, 5th edn. Mark Morris Institute, Topeka, pp 833鈥?53
  Raivio KO, Saksela M, Lapatto R (2014) Xanthine oxidoreductase鈥攔ole in human pathophysiology and in hereditary xanthinuria. In: Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson KM, Mitchell G (Eds.) The online metabolic and molecular bases of inherited disease. New York, NY: The McGraw-Hill Companies, Inc. http://鈥媤ww.鈥媜mmbid.鈥媘hmedical.鈥媍om/鈥媜mmbid.鈥?3/鈥? . Accessed 6 October 2014
  Ross SJ, Osborne CA, Lekcharoensuk C, Koehler LA, Polzin DJ (2007) A case鈥揷ontrol study of the effects of nephrolithiasis in cats with chronic kidney disease. J Am Vet Med Assoc 230:1854鈥?869CrossRef PubMed
  Schweighauser A, Howard J, Malik Y, Francey T (2009) Xanthinuria in a domestic shorthair cat. Vet Rec 164:91鈥?2CrossRef PubMed
  Sikora P, Pijanowska M, Majewski M, Bienia艣 B, Borzecka H, Zajczkowska M (2006) Acute renal failure due to bilateral xanthine urolithiasis in a boy with Lesch-Nyhan syndrome. Pediatr Nephrol 21:1045鈥?047CrossRef PubMed
  Sink CA, Weinstein NM (2012) Practical veterinary urinalysis. Routine urinalysis: microscopic elements, 1st edn. Wiley, West Sussex, pp 55鈥?12
  Torres M, Bardag铆 X, Zanna G, Ravera I, Ferrer L (2011) Long term follow-up of dogs diagnosed with leishmaniosis (clinical stage II) and treated with meglumine antimoniate and allopurinol. Vet J 188:346鈥?51CrossRef PubMed
  Tsuchida S, Kagi A, Hidekazu K, Tagawa M (2007) Xanthine urolithiasis in a cat: a case report and evaluation of a candidate gene for xanthine dehydrogenase. J Fel Med Surg 9:503鈥?08CrossRef
  Van Zuilen CD, Nickel RF, van Dijk TH, Reijngoud DJ (1997) Xanthinuria in a family of Cavalier King Charles spaniels. Vet Q 19:172鈥?74CrossRef PubMed
  White RN, Tick NT, White HL (1997) Naturally occurring xanthine urolithiasis in a domestic shorthair cat. J Small Anim Pract 38:299鈥?30CrossRef PubMed
  
• 作者单位：E. Furman (1)
  E. H. Hooijberg (1)
  J. Leidinger (1)
  C. Zedinger (2)
  E. Leidinger (1)
  U. Giger (3)
  
  1. Labor Invitro GmbH, Rennweg 95, 1030, Vienna, Austria
  2. TMA Ottakring, Vienna, Austria
  3. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pathology
  Hematology
  Oncology
  
• 出版者：Springer London
• ISSN：1618-565X

文摘

A 2-year-old domestic shorthair cat was presented with a history of hematuria, stranguria, and intermittent urethral obstruction. Urine sedimentation showed hematuria, pyuria, and yellow-brown, amorphous, and spherical crystals. Upon surgical correction of the obstructed urethra by perineal urethrostomy, many dark yellow to grey, irregular, gravel-like to millet grain-sized uroliths were found. These uroliths were shown to consist of 100 % xanthine by crystallography. The urinary xanthine concentration was high. The cat subsequently developed bilateral nephroliths, recurrent urinary tract infections, and chronic kidney failure. Dietary management with a low-purine diet failed in part due to poor compliance, and the cat was euthanized at 6 years of age. Xanthinuria is a rare inborn error of metabolism in cats and some other species but should be considered as a differential diagnosis in cases of feline urolithiasis. No associated molecular genetic defect has been elucidated, and management of these cases is difficult. In the absence of calculi for analysis, measuring urinary xanthine concentration can help in diagnosing this metabolic defect. Keywords Urine crystals Feline lower urinary tract disorders (FLUTD) Purine metabolism Metabolic disease Nephrolithiasis Uric acid