Expression of human T cell immunoglobulin domain and mucin-3 (TIM-3) on kidney tissue from systemic lupus erythematosus (SLE) patients

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• 作者：Ling Guo (1)
  Xiangdong Yang (1)
  Qing Xia (1)
  Junhui Zhen (2)
  Xuewei Zhuang (3)
  Tao Peng (1)
  
• 关键词：Human T cell immunoglobulin domain and mucin ; 3 (TIM ; 3) ; Systemic lupus erythematosus (SLE) ; Expression
• 刊名：Clinical and Experimental Medicine
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：14
• 期：4
• 页码：383-388
• 全文大小：720 KB
• 参考文献：1. Rus V, Atamas SP, Shustova V, Luzina IG, Selaru F, Magder LS et al (2002) Expression of cytokine-and chemokine-related genes in peripheral blood mononuclear cells from Lupus patients by cDNA array. Clin Immunol 102:283-90 CrossRef
  2. Rus V, Atamas SP, Shustova V (2003) Pathogenesis of systemic lupus erythematosus. Clin Pathol 56:481-90 CrossRef
  3. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T et al (2002) Th1-specific cell surface protein TIM-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415:536-41 CrossRef
  4. Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW et al (2010) T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology 139(6):2195-206 CrossRef
  5. Pan HF, Zhang N, Li WX, Tao JH, Ye DQ (2010) TIM-3 as a new therapeutic target in systemic lupus erythematosus. Mol Biol Rep 37(1):395-98 CrossRef
  6. Li X, Zhao YQ, Li CW, Yuan FL (2012) T cell immunoglobulin-3 as a new therapeutic target for rheumatoid arthritis. Expert Opin Ther Targets 16(12):1145-149 CrossRef
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  11. Li WX, Chen GM, Yuan H, Yao YS, Li RJ, Pan HF et al (2011) Polymorphisms of the TIM-1 and TIM-3 genes are not associated with systemic lupus erythematosus in a Chinese population. Mutagenesis 26(4):507-11 CrossRef
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  15. Chae SC, Park YR, Shim SC, Yoon KS, Chung HT (2004) The polymorphisms of Th1 cell surface gene TIM-3 are associated in a Korean population with rheumatoid arthritis. Immunol Lett 95(1):91-5 CrossRef
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• 作者单位：Ling Guo (1)
  Xiangdong Yang (1)
  Qing Xia (1)
  Junhui Zhen (2)
  Xuewei Zhuang (3)
  Tao Peng (1)
  
  1. Department of Nephrology, Shandong University Qilu Hospital, Jinan, 250012, China
  2. Department of Pathology, Shandong University Qilu Hospital, Jinan, China
  3. Department of Clinical Laboratory Medicine, Shandong University Qilu Hospital, Jinan, China
  
• ISSN：1591-9528

文摘

The aim of this study was to evaluate the expression of TIM-3 in renal tissue from patients with systemic lupus erythematosus (SLE) and patients without SLE, and to evaluate the difference of TIM-3 expression between them. A total of 272 patients with SLE as SLE group and 62 patients without SLE as control group were enrolled in the present study. Patients with SLE accepted percutaneous renal biopsy. We examined the expression of TIM-3 in renal tissue and the serological parameters in serum from all enrolled cases. The expression of TIM-3 and serological parameters were compared between the different groups. Positive staining of TIM-3 protein was seen in 97.1?% patients with SLE (264 out of 272), but 95.2?% negative staining in the cases without SLE (59 out of 62), only 3 out of 62 patients in control group were positive staining of TIM-3. There were significant differences between two groups in almost all serological markers which reflect SLE activity. There was a nearly positive correlation between pathological manifestations and expression degree of TIM-3. High immuno-reactivity of TIM-3 was found to be significantly correlated with serological grade (p?