An Artificial Supramolecular Nanozyme Based on ¦Â-Cyclodextrin-Modified Gold Nanoparticles

详细信息    查看全文

• 作者：Xiangqiu Li ; Zhenhui Qi ; Kai Liang ; Xiaolong Bai ; Jiayun Xu ; Junqiu Liu and Jiacong Shen
• 关键词：Nanoenzyme ; Supermolecule ; Thiolated ; cyclodextrin ; Gold nanoparticles ; Enzyme mimic
• 刊名：Catalysis Letters
• 出版年：2008
• 出版时间：August, 2008
• 年：2008
• 卷：124
• 期：3-4
• 页码：413-417
• 全文大小：325.1 KB

文摘

An artificial nanozyme model was developed by the supramolecular complexation of a β-cyclodextrin-modified gold nanoparticle and metal catalytic centers. The cyclodextrin-based monolayer was first constructed on the surface of gold nanoparticle by using the thiol modified cyclodextrin, subsequently the cyclodextrin-modified gold nanoparticle was utilized as a backbone to install metal catalytic centers by supramolecular assembly of the copper complex of triethylnetetramine-adamantane and β-cyclodextrin receptors immobilized on the surface of gold nanospheres via hydrophobic interaction. The catalytic behaviors of β-cyclodextrin-modified gold nanoparticles with adjacent multi-metal catalytic centers were investigated as an esterase mimic. Strong hydrolase activities for catalyzing the cleavage of an active ester 4,4′-dinitrodiphenyl carbonate (DNDPC) were observed. A detailed kinetic study on nanozyme-catalyzed hydrolysis of ester DNDPC has been described.