Attenuated live vaccine (Bartha-K16) caused pseudorabies (Aujeszky’s disease) in sheep

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• 作者：Hanjin Kong (1) (2)
  Keshan Zhang (1)
  Yongjie Liu (1)
  Youjun Shang (1)
  Bin Wu (2)
  Xiangtao Liu (1) (3)
  
• 关键词：Live attenuated vaccine ; Bartha ; K16 strain ; Pseudorabies virus ; Sheep ; Safety
• 刊名：Veterinary Research Communications
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：37
• 期：4
• 页码：329-332
• 全文大小：
• 作者单位：Hanjin Kong (1) (2)
  Keshan Zhang (1)
  Yongjie Liu (1)
  Youjun Shang (1)
  Bin Wu (2)
  Xiangtao Liu (1) (3)
  
  1. State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China
  2. State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, People’s Republic of China
  3. Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping No.1, Yanchangpu, Lanzhou, Gansu, 730046, People’s Republic of China
  
• ISSN：1573-7446

文摘

Pseudorabies (PR, Aujeszky’s disease) is an acute, contagious viral disease that affects a wide range of domestic and wild species. In the present study, an outbreak of PR in sheep induced by attenuated live vaccine (Bartha-K16) was diagnosed and analyzed in China. The presence of PR virus (PRV) in brain samples from infected sheep was confirmed by gC gene polymerase chain reaction amplification and PRV-like particle observation by electron microscopy. The molecular characterization of the PRV was performed with homology analysis and phylogenetic tree construction based on the gC gene. This is the first description of an outbreak of PR induced by a live attenuated vaccine (Bartha-K16), indicating that this vaccine is unsuitable for use in sheep.