Patients with type 2 diabetes exhibit cognitive impairment with changes of metabolite concentration in the left hippocampus

详细信息    查看全文

• 作者：Yue Wang ; Xiao-yun Xu ; Chun-hua Feng ; Yuan-ling Li ; Xia Ge…
• 关键词：Type 2 diabetes mellitus ; Cognitive function ; Metabolite ; Proton magnetic resonance spectroscopy
• 刊名：Metabolic Brain Disease
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：30
• 期：4
• 页码：1027-1034
• 全文大小：402 KB
• 参考文献：Bastos-Leite AJ, Kuijer JP, Rombouts SA, Sanz-Arigita E, van Straaten EC, Gouw AA, van der Flier WM, Scheltens P, Barkhof F (2008) Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities. AJNR Am J Neuroradiol 29(7):1296-301PubMed View Article
  Biessels GJ, Deary IJ, Ryan CM (2008) Cognition and diabetes: a lifespan perspective. Lancet Neurol 7(2):184-90PubMed View Article
  Fisher SK, Novak JE, Agronoff BE (2002) Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem 82(4):736-54PubMed View Article
  Gatto NM, Henderson VW, St John JA, McCleary C, Hodis HN, Mack WJ (2008) Metabolic syndrome and cognitive function in healthy middle-aged and older adults without diabetes. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 15(5):627-41PubMed Central PubMed View Article
  Gong YX (1989) Wechsler memory scale - revised in China. Hunan Medical University Publishing, Hunan [in Chinese]
  Gujar SK, Maheshwari S, Bj?rkman-Burtscher I, Sundgren PC (2005) Magnetic resonance spectroscopy. J Neuroophthalmol 25(3):217-26PubMed View Article
  Haley AP, Gonzales MM, Tarumi T, Miles SC, Goudarzi K, Tanaka H (2010) Elevated cerebral glutamate and myo-inositol levels in cognitively normal middle-aged adults with metabolic syndrome. Metab Brain Dis 25(4):397-05PubMed View Article
  Heikkil? O, Lundbom N, Timonen M, Groop PH, Heikkinen S, M?kimattila S (2008) Risk for metabolic syndrome predisposes to alterations in the thalamic metabolism. Metab Brain Dis 23(3):315-24PubMed View Article
  Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, Rapoport SI, Schapiro MB (2001) Brain metabolite concentration and dementia severity in Alzheimer’s disease: a (1) H MRS study. Neurology 57(4):626-32PubMed View Article
  Jefferies E (2013) The neural basis of semantic cognition: converging evidence from neuropsychology, neuroimaging and TMS. Cortex 49(3):611-25PubMed View Article
  Li G, Xu X, Wang D, Wang J, Wang Y, Yu J (2011) Microglial activation during acute cerebral infarction in the presence of diabetes mellitus. Neurol Sci 32(6):1075-079PubMed View Article
  Modi S, Bhattacharya M, Sekhri T, Rana P, Tripathi RP, Khushu S (2008) Assessment of the metabolic profile in type 2 diabetes mellitus and hypothyroidism through proton MR spectroscopy. Magn Reson Imaging 26(3):420-25PubMed View Article
  Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM (2007) N-acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 81(2):89-31PubMed Central PubMed View Article
  Musen G, Lyoo IK, Sparks CR, Weinger K, Hwang J, Ryan CM, Jimerson DC, Hennen J, Renshaw PF, Jacobson AM (2006) Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry. Diabetes 55(2):326-33PubMed View Article
  Park CR (2001) Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25(4):311-23PubMed View Article
  Ross B, Bluml S (2001) Magnetic resonance spectroscopy of the human brain. Anat Rec 265(2):54-4PubMed View Article
  Ross AJ, Sachdev PS (2004) Magnetic resonance spectroscopy in cognitive research. Brain Res Rev 44(2-):83-02PubMed View Article
  Sahin I, Alkan A, Keskin L, Cikim A, Karakas HM, Firat AK, Sigirci A (2008) Evaluation of in vivo cerebral metabolism on proton magnetic resonance spectroscopy in patients with impaired glucose tolerance and type 2 diabetes mellitus. J Diabetes Complicat 22(4):254-60PubMed View Article
  Sarac K, Akinci A, Alkan A, Aslan M, Baysal T, Ozcan C (2005) Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus. Neuroradiology 47(7):562-65PubMed View Article
  Schaefer M, Heinze HJ, Rotte M (2006) Verbal memory encoding in patients with left-sided hippocampal sclerosis. Neuroreport 17(11):1219-223PubMed View Article
  Smith EE, Jonides J (1999) Storage and executive processes in the frontal lobes. Science 283(5408):1657-661PubMed View Article
  van der Graaf M, Janssen SW, van Asten JJ, Hermus AR, Sweep CG, Pikkemaat JA, Martens GJ, Heerschap A (2004) Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo 1H magnetic resonance spectroscopy. NMR Biomed 17(6):405-10PubMed View Article
  van Harten B, de Leeuw FE, Weinstein HC, Scheltens P, Biessels GJ (2006) Brain imaging in patients with diabetes: a systematic review. Diabetes Care 29(11):2539-548PubMed View Article
  Vrenken H, Barkhof F, Uitdehaag BM, Castelijns JA, Polman CH, Pouwels PJ (2005) MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter. Magn Reson Med 53(2):256-66PubMed View Article
  Watanabe T, Shiino A, Akiguchi I (2012) Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alz
• 作者单位：Yue Wang (1)
  Xiao-yun Xu (2)
  Chun-hua Feng (1)
  Yuan-ling Li (1)
  Xia Ge (1)
  Gen-lin Zong (3)
  Yi-bin Wang (3)
  Bo Feng (4)
  Peng Zhang (5)
  
  1. Department of Neurology, East Hospital, Tongji University, Shanghai, China
  2. Department of Neurology, Pudong New Area Zhoupu Hospital, Shanghai, China
  3. Department of Radiology, East Hospital, Tongji University, Shanghai, China
  4. Department of Endocrinology, East Hospital, Tongji University, Shanghai, China
  5. Shanghai Pudong New Area Center for Disease Control & Prevention, Shanghai, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Biochemistry
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7365

文摘

Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction. Previous studies have reported the relationship between cerebral metabolite changes and glucose levels. However, the specific aspects of cognition that are affected by metabolic changes in T2DM- related cognitive impairment remain undetermined. In this study, 188 T2DM patients and 266 controls were recruited. Proton magnetic resonance spectra with a single voxel stimulated echo acquisition mode (STEAM) were acquired from the left hippocampus and the frontal lobe. Presence of T2DM negatively affected the scores of Mini-Mental State Examination (MMSE), sub-tests (i.e., attention and language) of MMSE, Montreal Cognitive Assessment (MoCA) according to the Beijing version, and sub-tests (i.e., visuospatial/executive reasoning, attention, and language) of MoCA, rather than the Wechsler Memory Scale -Revised in China (WMS-RC), and all memory sub-tests contained with the MMSE and MoCA frameworks. T2DM positively affected creatine and myoinositol peak areas from the left hippocampus, rather than metabolites in the left frontal lobe. Negative correlations were shown between the left hippocampal myoinositol levels and language scores, and between the left hippocampal creatine levels and visuospatial/executive scores in T2DM. These findings suggest that T2DM may be an independent risk factor for cognitive impairment. Further, the cognitive domains of visuospatial /executive reasoning, attention and language may be predominantly impaired in the early phases of T2DM-related cognitive impairment. In addition, left hippocampal myoinositol and creatine concentrations were associated with cognitive impairment in patients with T2DM.