Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians

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• 作者：Yan Han ; Shuai Wu ; Qiang Hu ; Jian-Qi Xiao ; Dong-Mei Wei…
• 关键词：Cerebral infarction ; Thrombomodulin ; High ; sensitive C ; reactive protein ; Meta ; analysis
• 刊名：Molecular Neurobiology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：53
• 期：4
• 页码：2659-2667
• 全文大小：676 KB
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• 作者单位：Yan Han (1)
  Shuai Wu (1)
  Qiang Hu (2)
  Jian-Qi Xiao (3)
  Dong-Mei Wei (4)
  Li-Li Liu (5)
  Ze-Zhi Li (6)
  
  1. Department of Neurology, Shanghai Changhai Hospital, Secondary Military Medical University, Shanghai, China
  2. Department of Psychology, Qiqihar Mental Health Center, Qiqihar, 161000, China
  3. Department of Neurosurgery, The First Hospital of Qiqihar City, Qiqihar, 161000, China
  4. Department of Traditional Chinese Medicine, The First Hospital of Qiqihar City, Qiqihar, 161000, China
  5. Department of Neurology, Shanghai Houkou District Jiangwan Hospital, Shanghai, China
  6. Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Our meta-analysis was designed to obtain the correlation between thrombomodulin (TM) and high-sensitive C-reactive protein (hs-CRP) levels and the development of cerebral infarction (CI). Case–control studies relevant to the role plasma TM levels and serum hs-CRP levels in the development of CI were retrieved both electronically and manually and further screened according to a predetermined inclusion and exclusion criteria. All enrolled studies were analyzed for meta-regression analyses, sensitivity analyses, and assessments of publication bias. Comprehensive Meta-analysis 2.0 software (CMA 2.0) was used for statistical analysis. A total of 359 studies were initially retrieved, and 13 studies were eventually recruited into our meta-analysis with a total of 881 CI patients (plasma TM levels: n = 513; serum hs-CRP levels: n = 368) and 1067 healthy controls. The results of our meta-analysis suggested that plasma TM levels and serum hs-CRP levels in CI patients were significantly higher than those in healthy controls. In conclusion, increased plasma TM levels and serum hs-CRP levels in CI patients were associated with the development of CI in Asians.