Citrate Attenuates Adenine-Induced Chronic Renal Failure in Rats by Modulating the Th17/Treg Cell Balance

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• 作者：Yan Ou ; Shuiqin Li ; Xiaojing Zhu ; Baosong Gui ; Ganglian Yao ; Liqun Ma…
• 关键词：citrate ; Th17 cells ; regulatory T cells ; chronic renal failure
• 刊名：Inflammation
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：39
• 期：1
• 页码：79-86
• 全文大小：1,191 KB
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• 作者单位：Yan Ou (1)
  Shuiqin Li (2)
  Xiaojing Zhu (1)
  Baosong Gui (1)
  Ganglian Yao (1)
  Liqun Ma (1)
  Dan Zhu (1)
  Rongguo Fu (1)
  Heng Ge (1)
  Li Wang (1)
  Lining Jia (1)
  Lifang Tian (1)
  Zhaoyang Duan (1)
  
  1. Department of Nephrology, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 the Fifth Western Street, Xi’an, 710004, Shaanxi, China
  2. Department of Rehabilitation Medicine, Yan’an University Affiliated Hospital, Yan’an, 716000, Shaanxi, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Citrate is commonly used as an anticoagulant in hemodialysis for chronic renal failure (CRF) and for the regulation of the immune dysfunction in CRF patients. The objective of this study was to investigate the effect of citrate on the balance of T helper 17 (Th17) and regulatory T (Treg) cells in CRF. The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were significantly increased in the CRF model group compared to the control group, and were decreased in the citrate-treated groups. Citrate treatment inhibited the viability of Th17 cells while elevating the viability of Treg cells in CRF rats. Moreover, Th17-related cytokines significantly decreased while the Treg-related cytokines significantly increased with citrate treatment. Moreover, citrate had a negative influence on the deviation of Th17/Treg cells in CRF rats. Therefore, our study suggests that citrate had an anti-inflammatory effect on CRF through the modulation of the Th17/Treg balance. KEY WORDS citrate Th17 cells regulatory T cells chronic renal failure