Single nucleotide polymorphisms at the TRAF1/C5 locus are associated with rheumatoid arthritis in a Han Chinese population

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• 作者：Jing Zhu (1) (2)
  Dinging Zhang (2) (3)
  Fengxia Wu (4)
  Fei He (2) (3)
  Xiaoqi Liu (2) (3)
  Lijun Wu (5)
  Bin Zhou (1)
  Jianping Liu (4)
  Fang Lu (2) (3)
  Jian Liu (1)
  Ruijun Luo (2)
  Wubin Long (1)
  Minghui Yang (4)
  Shi Ma (2) (3)
  Xiaodan Wu (1)
  Yi Shi (2) (3)
  Tong Wu (1)
  Ying Lin (2) (3)
  Jiyun Yang (2) (3)
  Guohua Yuan (4)
  Zhenglin Yang (2) (3)
  
• 关键词：rheumatoid arthritis ; genetics ; TRAF1/C5 ; association study ; Chinese
• 刊名：BMC Medical Genetics
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：12
• 期：1
• 全文大小：234KB
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  53. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2350/12/53/prepub
  
• 作者单位：Jing Zhu (1) (2)
  Dinging Zhang (2) (3)
  Fengxia Wu (4)
  Fei He (2) (3)
  Xiaoqi Liu (2) (3)
  Lijun Wu (5)
  Bin Zhou (1)
  Jianping Liu (4)
  Fang Lu (2) (3)
  Jian Liu (1)
  Ruijun Luo (2)
  Wubin Long (1)
  Minghui Yang (4)
  Shi Ma (2) (3)
  Xiaodan Wu (1)
  Yi Shi (2) (3)
  Tong Wu (1)
  Ying Lin (2) (3)
  Jiyun Yang (2) (3)
  Guohua Yuan (4)
  Zhenglin Yang (2) (3)
  
  1. Department of Rheumatology and Immunology, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China
  2. Center for Human Molecular Biology & Genetics, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China
  3. Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China
  4. Institute of Rheumatology and Immunology, Affiliated Hospital, North Sichuan Medical College, Nanchong, Sichuan, China
  5. Department of Rheumatology, People’s Hospital of Xin Jiang Uygur Autonomous Region, Urumchi, Xin Jiang, China
  
• ISSN：1471-2350

文摘

Background Genetic variants in TRAF1C5 and PTPN22 genes have been shown to be significantly associated with arthritis rheumatoid in Caucasian populations. This study investigated the association between single nucleotide polymorphisms (SNPs) in TRAF1/C5 and PTPN22 genes and rheumatoid arthritis (RA) in a Han Chinese population. We genotyped SNPs rs3761847 and rs7021206 at the TRAF1/C5 locus and rs2476601 SNP in the PTPN22 gene in a Han Chinese cohort composed of 576 patients with RA and 689 controls. The concentrations of anti-cyclic citrullinated peptide antibodies (CCP) and rheumatoid factor (RF) were determined for all affected patients. The difference between the cases and the controls was compared using χ 2 analysis. Results Significant differences in SNPs rs3761847 and rs7021206 at TRAF1/C5 were observed between the case and control groups in this cohort; the allelic p-value was 0.0018 with an odds ratio of 1.28 for rs3761847 and 0.005 with an odds ratio of 1.27 for rs7021206. This significant association between rs3761847 and RA was independent of the concentrations of anti-CCP and RF. No polymorphism of rs2476601 was observed in this cohort. Conclusions We first demonstrated that genetic variants at the TRAF1/C5 locus are significantly associated with RA in Han Chinese, suggesting that TRAF1/C5 may play a role in the development of RA in this population, which expands the pathogenesis role of TRAF1/C5 in a different ethnicity.