Prevalence of enteroviruses in children with and without hand, foot, and mouth disease in China

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• 作者：Xiaoai Zhang (6)
  Hongyu Wang (5) (6)
  Shujun Ding (7)
  Xianjun Wang (7)
  Xiaodan Chen (6)
  Ying Wo (6)
  Liyuan Wang (5) (6)
  Doudou Huang (5) (6)
  Wei Liu (6)
  Wuchun Cao (6)
  
• 关键词：Hand ; foot ; and mouth disease ; Enterovirus ; Epidemiology
• 刊名：BMC Infectious Diseases
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：13
• 期：1
• 全文大小：330 KB
• 参考文献：1. Solomon T, Lewthwaite P, Perera D, Cardosa MJ, McMinn P, Ooi MH: Virology, epidemiology, pathogenesis, and control of enterovirus 71. / Lancet Infect Dis 2010,10(11):778-90. CrossRef
  2. Yip CC, Lau SK, Woo PC, Yuen KY: Human enterovirus 71 epidemics: what’s next? / Emerg Health Threats J 2013, 6:19780.
  3. Zhang Y, Tan XJ, Wang HY, Yan DM, Zhu SL, Wang DY, Ji F, Wang XJ, Gao YJ, Chen L, / et al.: An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. / J Clin Virol 2009,44(4):262-67. CrossRef
  4. Yang F, Ren L, Xiong Z, Li J, Xiao Y, Zhao R, He Y, Bu G, Zhou S, Wang J, / et al.: Enterovirus 71 outbreak in the People’s Republic of China in 2008. / J Clin Microbiol 2009,47(7):2351-352. CrossRef
  5. He SJ, Han JF, Ding XX, Wang YD, Qin CF: Characterization of enterovirus 71 and coxsackievirus A16 isolated in hand, foot, and mouth disease patients in Guangdong, 2010. / Int J Infect Dis 2013,17(11):e1025-030. CrossRef
  6. Lu QB, Zhang XA, Wo Y, Xu HM, Li XJ, Wang XJ, Ding SJ, Chen XD, He C, Liu LJ, / et al.: Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009-011. / PLoS One 2012,7(12):e52073. CrossRef
  7. Yang F, Zhang T, Hu Y, Wang X, Du J, Li Y, Sun S, Sun X, Li Z, Jin Q: Survey of enterovirus infections from hand, foot and mouth disease outbreak in China, 2009. / Virol J 2011, 8:508. CrossRef
  8. Tseng FC, Huang HC, Chi CY, Lin TL, Liu CC, Jian JW, Hsu LC, Wu HS, Yang JY, Chang YW, / et al.: Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data. / J Med Virol 2007,79(12):1850-860. CrossRef
  9. Han J, Ma XJ, Xu WB, Wan JF, Li Q, Tian C, Gao C, Wang M, Tang LY, Zhang Y, / et al.: EV71 viral secretion by symptomatic hand foot and mouth disease patients and their asymptomatic close contacts. / J Infect 2011,62(1):107-08. CrossRef
  10. Witso E, Palacios G, Cinek O, Stene LC, Grinde B, Janowitz D, Lipkin WI, Ronningen KS: High prevalence of human enterovirus a infections in natural circulation of human enteroviruses. / J Clin Microbiol 2006,44(11):4095-100. CrossRef
  11. Simonen-Tikka ML, Hiekka AK, Klemola P, Poussa T, Ludvigsson J, Korpela R, Vaarala O, Roivainen M: Early human enterovirus infections in healthy Swedish children participating in the PRODIA pilot study. / J Med Virol 2012,84(6):923-30. CrossRef
  12. Verstrepen WA, Bruynseels P, Mertens AH: Evaluation of a rapid real-time RT-PCR assay for detection of enterovirus RNA in cerebrospinal fluid specimens. / J Clin Virol 2002,25(Suppl 1):S39-S43. CrossRef
  13. Nix WA, Oberste MS, Pallansch MA: Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. / J Clin Microbiol 2006,44(8):2698-704. CrossRef
  14. Xu M, Su L, Cao L, Zhong H, Dong N, Xu J: Enterovirus genotypes causing hand foot and mouth disease in Shanghai, China: a molecular epidemiological analysis. / BMC Infect Dis 2013,13(1):489. CrossRef
  15. Zhang L, Chen QY, Liu H, Tang LQ, Mai HQ: Emerging treatment options for nasopharyngeal carcinoma. / Drug Des Devel Ther 2013, 7:37-2.
  16. He YQ, Chen L, Xu WB, Yang H, Wang HZ, Zong WP, Xian HX, Chen HL, Yao XJ, Hu ZL, / et al.: Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6- and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China. / J Clin Microbiol 2013,51(11):3560-566. CrossRef
  17. Cabrerizo M, Tarrago D, Munoz-Almagro C, Del Amo E, Dominguez-Gil M, Eiros JM, Lopez-Miragaya I, Perez C, Reina J, Otero A, / et al.: Molecular epidemiology of enterovirus 71, coxsackievirus A16 and A6 associated with hand, foot and mouth disease in Spain. / Int J Infect Dis 2013. in press
  18. Park SH, Choi SS, Oh SA, Kim CK, Cho SJ, Lee JH, Ryu SH, Pak SH, Jung SK, Lee JI, / et al.: Detection and characterization of enterovirus associated with herpangina and hand, foot, and mouth disease in Seoul, Korea. / Clin Lab 2011,57(11-2):959-67.
  19. Gopalkrishna V, Patil PR, Patil GP, Chitambar SD: Circulation of multiple enterovirus serotypes causing hand, foot and mouth disease in India. / J Med Microbiol 2012,61(Pt 3):420-25. CrossRef
  20. Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, Quak SH, Chow VT: The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. / Int J Infect Dis 2010,14(12):e1076-e1081. CrossRef
  21. Fujimoto T, Iizuka S, Enomoto M, Abe K, Yamashita K, Hanaoka N, Okabe N, Yoshida H, Yasui Y, Kobayashi M, / et al.: Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011. / Emerg Infect Dis 2012,18(2):337-39. CrossRef
  22. Montes M, Artieda J, Pineiro LD, Gastesi M, Diez-Nieves I, Cilla G: Hand, foot, and mouth disease outbreak and coxsackievirus A6, northern Spain, 2011. / Emerg Infect Dis 2013,19(4):676-78. CrossRef
  23. Flett K, Youngster I, Huang J, McAdam A, Sandora TJ, Rennick M, Smole S, Rogers SL, Nix WA, Oberste MS, / et al.: Hand, foot, and mouth disease caused by coxsackievirus a6. / Emerg Infect Dis 2012,18(10):1702-704. CrossRef
  24. Puenpa J, Chieochansin T, Linsuwanon P, Korkong S, Thongkomplew S, Vichaiwattana P, Theamboonlers A, Poovorawan Y: Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand, 2012. / Emerg Infect Dis 2013,19(4):641-43. CrossRef
  25. Huang WC, Huang LM, Lu CY, Cheng AL, Chang LY: Atypical hand-foot-mouth disease in children: a hospital-based prospective cohort study. / Virol J 2013, 10:209. CrossRef
  26. Chang LY, Lin TY, Huang YC, Tsao KC, Shih SR, Kuo ML, Ning HC, Chung PW, Kang CM: Comparison of enterovirus 71 and coxsackie-virus A16 clinical illnesses during the Taiwan enterovirus epidemic, 1998. / Pediatr Infect Dis J 1999,18(12):1092-096. CrossRef
  27. Tan X, Huang X, Zhu S, Chen H, Yu Q, Wang H, Huo X, Zhou J, Wu Y, Yan D, / et al.: The persistent circulation of enterovirus 71 in People’s Republic of China: causing emerging nationwide epidemics since 2008. / PLoS One 2011,6(9):e25662. CrossRef
  28. Yang F, Du J, Hu Y, Wang X, Xue Y, Dong J, Sun L, Li Z, Li Y, Sun S, / et al.: Enterovirus coinfection during an outbreak of hand, foot, and mouth disease in Shandong, China. / Clin Infect Dis 2011,53(4):400-01. CrossRef
  29. Wu W, Xu WB, Chen L, Chen HL, Liu Q, Wang DL, Chen YJ, Yao W, Li G, Feng B, / et al.: Molecular identification and analysis of human enteroviruses isolated from healthy children in shenzhen, china from 2010 to 2011. / PLoS One 2013,8(6):e64889. CrossRef
  30. Witso E, Palacios G, Ronningen KS, Cinek O, Janowitz D, Rewers M, Grinde B, Lipkin WI: Asymptomatic circulation of HEV71 in Norway. / Virus Res 2007,123(1):19-9. CrossRef
  31. Cinek O, Witso E, Jeansson S, Rasmussen T, Drevinek P, Wetlesen T, Vavrinec J, Grinde B, Ronningen KS: Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes. / J Clin Virol 2006,35(1):33-0. CrossRef
  32. Kuramitsu M, Kuroiwa C, Yoshida H, Miyoshi M, Okumura J, Shimizu H, Narantuya L, Bat-Ochir D: Non-polio enterovirus isolation among families in Ulaanbaatar and Tov province, Mongolia: prevalence, intrafamilial spread, and risk factors for infection. / Epidemiol Infect 2005,133(6):1131-142. CrossRef
  33. Honkanen H, Oikarinen S, Pakkanen O, Ruokoranta T, Pulkki MM, Laitinen OH, Tauriainen S, Korpela S, Lappalainen M, Vuorinen T, / et al.: Human enterovirus 71 strains in the background population and in hospital patients in Finland. / J Clin Virol 2013,56(4):348-53. CrossRef
  34. Li W, Yi L, Su J, Lu J, Zeng H, Guan D, Ma C, Zhang W, Xiao H, Li H, / et al.: Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China. / BMC Infect Dis 2013, 13:322. CrossRef
  35. Yip CC, Lau SK, Lo JY, Chan KH, Woo PC, Yuen KY: Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong. / Virol J 2013, 10:222. CrossRef
  36. Chang LY, Tsao KC, Hsia SH, Shih SR, Huang CG, Chan WK, Hsu KH, Fang TY, Huang YC, Lin TY: Transmission and clinical features of enterovirus 71 infections in household contacts in Taiwan. / JAMA 2004,291(2):222-27. CrossRef
  37. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2334/13/606/prepub
  
• 作者单位：Xiaoai Zhang (6)
  Hongyu Wang (5) (6)
  Shujun Ding (7)
  Xianjun Wang (7)
  Xiaodan Chen (6)
  Ying Wo (6)
  Liyuan Wang (5) (6)
  Doudou Huang (5) (6)
  Wei Liu (6)
  Wuchun Cao (6)
  
  6. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dong-Da Street, Fengtai District, Beijing, 100071, P. R. China
  5. Graduate School of Anhui Medical University, 230032, Hefei, P. R. China
  7. Shandong Provincial Center for Disease Control and Prevention, 250001, Jinan, P. R. China
  
• ISSN：1471-2334

文摘

Background To determine the prevalence of human enteroviruses (HEVs) among healthy children, their parents, and children with hand, foot, and mouth disease (HFMD). Methods We conducted a case–control study that included throat samples from 579 children with HFMD and from 254 healthy controls. Throat samples from 49 households (98 parents and 53 healthy children) were also analyzed. Phylogenetic analysis was carried out to study genetic relationships of EV71 strains. Results The HEV positive rate in HFMD patients was significantly higher than that in healthy controls (76.0% vs. 23.2%, P-lt;-.001). The EV71 (43.7% vs. 15.0%, P-lt;-.001), CVA16 (18.0% vs. 2.8%, P-lt;-.001), and CVA10 (5.7% vs. 0.8%, P--.001) serotypes were significantly overrepresented in HFMD patients in comparison to healthy children. Other HEV serotypes were detected with comparable frequency in cases and controls. The HEV positive rate in severe HFMD patients was significantly higher than that in mild group (82.1% vs. 73.8%, P--.04). The EV71 (55.0% vs. 39.7%, P--.001) and CVA16 (11. 9% vs. 20.0%, P--.024) positive rate differed significantly between severe and mild HFMD patients. Other HEV serotypes were detected with comparable frequency between severe and mild HFMD patients. Among 49 households, 22 households (44.9%) had at least 1 family member positive for HEV. Children had significantly higher HEV positive rate than adult (28.3% vs. 14.3%, P--.037). The HEV positive rate was similar between mothers and fathers (12.24% vs. 16.32%, P--.56). The VP1 sequences of EV71 from HFMD patients and healthy children were nearly identical and all were clustered in the same clade, C4a. Conclusions Our study demonstrated the co-circulation of multiple HEV serotypes in children with and without HFMD during epidemic. Our study deserves the attention on HFMD control.