Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

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• 作者：Fengjiao Wu ; Qiang Zou ; Xiaodan Ding ; Dongyan Shi…
• 关键词：Complement ; CNS inflammation ; Intravital microscopy ; Adhesion molecule ; Leukocyte recruitment
• 刊名：Journal of Neuroinflammation
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：13
• 期：1
• 全文大小：3,773 KB
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• 作者单位：Fengjiao Wu (1)
  Qiang Zou (2)
  Xiaodan Ding (1)
  Dongyan Shi (1)
  Xingxing Zhu (1)
  Weiguo Hu (3)
  Lixin Liu (4)
  Hong Zhou (1)
  
  1. Department of Immunology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, JS, 210029, China
  2. Department of Immunology, Chengdu Medical College, Chengdu, 610083, Sichuan, China
  3. Shanghai Cancer Center and Institute of Biomedical Science, Shanghai Medical College, Shanghai Cancer Center, Fudan University, Shanghai, 200032, China
  4. Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5, Canada
  
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094

文摘

Background The complement system is becoming increasingly recognized as a key participant in many neurodegenerative diseases of the brain. Complement-deficient animals exhibit reduced neuroinflammation.