Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma

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• 作者：Jingli Du (1)
  Yulan Wang (2)
  Hanjiang Fu (3)
  Xiaofei Zheng (3)
  Minggui Lin (4)
  Mingzhou Guo (5)
  Lixin Wei (1)
  
• 关键词：miR ; 10b ; RHOC ; Hepatocellular carcinoma ; miRNA ; Metastasis
• 刊名：Chinese Science Bulletin
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：59
• 期：19
• 页码：2249-2253
• 全文大小：
• 参考文献：1. Tung P, Poon R, Fan ST et al (2000) Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. Am Surg 232:10-4
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• 作者单位：Jingli Du (1)
  Yulan Wang (2)
  Hanjiang Fu (3)
  Xiaofei Zheng (3)
  Minggui Lin (4)
  Mingzhou Guo (5)
  Lixin Wei (1)
  
  1. Department of Pathology, Chinese PLA General Hospital, Beijing, 100853, China
  2. Department of Pathology, Urumqi General Hospital, Lanzhou Military District, Urumqi, 830054, China
  3. Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, 100850, China
  4. Institute of Tuberculosis, 309th Hospital PLA, Beijing, 100091, China
  5. Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, 100853, China
  
• ISSN：1861-9541

文摘

Aberrant expression of microRNAs (miRNAs) was reported frequently in different human cancers. The major role of miRNA is targeting 3-UTR of coding gene and causing translational repression or mRNA degradation. miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression. But its expression in hepatocellular carcinoma (HCC) remains unclear. Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples, and reduced expression of miR-10b in HCC was related to vein invasion. High-level expression of RHOC was also related to vein invasion in HCC. But no correlation was found between miR-10b and RHOC expression. These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis.