Tunable thermo-responsive supramolecular hydrogel: design, characterization, and drug release

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• 作者：Mi Zhou ; Xiaofeng Ye ; Kaiyue Liu ; Jingying Hu ; Xin Qian
• 关键词：Thermo ; responsive ; Supramolecular hydrogel ; Drug delivery ; Self ; assembly
• 刊名：Journal of Polymer Research
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：22
• 期：9
• 全文大小：1,724 KB
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• 作者单位：Mi Zhou (1)
  Xiaofeng Ye (1)
  Kaiyue Liu (1)
  Jingying Hu (1)
  Xin Qian (1)
  
  1. College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Industrial Chemistry and Chemical Engineering
  Characterization and Evaluation Materials
  
• 出版者：Springer Netherlands
• ISSN：1572-8935

文摘

During the past decade, a series of thermo-responsive hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) were prepared for drug delivery. However, the release performance of those hydrogels was limited because the LCST (lower critical solution temperature) of PNIPAM (about 32?°C) is slightly lower than human body temperature, and the drug loading is complicated. To develop a new drug delivery matrix with the suitable responsive interval, a novel, temperature-sensitive copolymer with two monomers, N-isopropylacrylamide and methylacrylic polyethylene glycol monomethyl ether ester (MPEGMA) [poly(NIPAM-co-MPEGMA)], was synthesized by free radical polymerization. Then, the supramolecular hydrogels with tunable response temperature, whose structures were confirmed by X-ray diffraction (XRD), were fabricated via inclusion complexation with α-cyclodextrin (α-CD) and the copolymers in aqueous solution. The rheology results indicated that response interval could be modulated by controlling the contents of PNIPAM in the copolymers. Compared to the normal PNIPAM ge1, the succinct method of gel preparation streamlined the process of loading and made the drug loading capacity controllable. The release time was proved to be prolonged by the release kinetics of 5-fluoroucrail (5-Fu), which showed feasibility as a drug delivery.