Chronic kidney disease after autologous stem cell transplantation: analysis of a single center experience

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• 作者：QiaoYuan Wu (1)
  XiaoHong Li (1)
  YongRong Lai (2)
  ZhiGang Peng (2)
  YunHua Liao (1)
  
• 关键词：Autologous ; Hematopoietic stem cell transplantation (HSCT) ; Chronic kidney disease (CKD) ; Mesangial proliferative glomerulonephritis ; Proteinuria
• 刊名：International Urology and Nephrology
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：46
• 期：7
• 页码：1403-1410
• 全文大小：452 KB
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• 作者单位：QiaoYuan Wu (1)
  XiaoHong Li (1)
  YongRong Lai (2)
  ZhiGang Peng (2)
  YunHua Liao (1)
  
  1. Department of Nephrology, The First Affiliated Hospital, Guangxi Medical University, No. 22, Shuang Yong Lu, Nanning, 530021, Guangxi, China
  2. Department of Hematology, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, Guangxi, China
  
• ISSN：1573-2584

文摘

Purpose Chronic kidney disease (CKD) after allogeneic hematopoietic stem cell transplantation (HSCT) has increasingly been reported. However, CKD after autologous HSCT, especially changes in renal pathology, has rarely been reported. This study aimed to evaluate the frequency of CKD among patients who received autologous HSCT for hematological and nonhematological disorders, and analyze its clinical and pathological features. Methods We performed a retrospective study to evaluate the frequency of CKD after autologous HSCT and analyzed clinical and pathological features of CKD. Clinical records of patients who underwent autologous HSCT at the First Affiliated Hospital of Guangxi Medical University between May 2000 and November 2010 were screened. Clinical data of those with kidney injury on presentation and follow-up were acquired from hospital records. Results A total of 41 patients who received autologous HSCT were identified. CKD developed in six patients (14.6?%). Among the six patients, all had various degrees of proteinuria and three patients had nephrotic syndrome. Impaired renal function occurred in three patients. Three patients with nephrotic syndrome received only prednisone. Two patients obtained complete remission, and one had partial remission. What is particularly worth mentioning is, in two patients who received renal biopsy in our study, the pathological changes were mesangial proliferative glomerulonephritis. Conclusions Mesangial proliferative glomerulonephritis may not be as uncommon as previously thought in CKD patients after autologous HSCT. Presentation of nephrotic syndrome is common in CKD after HSCT and prednisone alone are effective.