Trophectoderm morphology predicts outcomes of pregnancy in vitrified-warmed single-blastocyst transfer cycle in a Chinese population
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- 作者：Xiaojiao Chen (1)
Junqiang Zhang (1) (2)
Xun Wu (1)
Shanren Cao (1)
Lin Zhou (1)
Ying Wang (1)
Xin Chen (1)
Jin Lu (1)
Chun Zhao (1)
Minjian Chen (3)
Xiufeng Ling (1) - 关键词：Blastocyst grading ; Trophectoderm ; Vitrified ; warmed single ; blastocyst transfer ; Clinical pregnancy ; Live birth
- 刊名：Journal of Assisted Reproduction and Genetics
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：31
- 期：11
- 页码：1475-1481
- 全文大小：717 KB
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16. Ahlstrom A, Westin C, Reismer - 作者单位：Xiaojiao Chen (1)
Junqiang Zhang (1) (2)
Xun Wu (1)
Shanren Cao (1)
Lin Zhou (1)
Ying Wang (1)
Xin Chen (1)
Jin Lu (1)
Chun Zhao (1)
Minjian Chen (3)
Xiufeng Ling (1)
1. State Key Laboratory of Reproductive Medicine, Department of Reproduction, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, 210004, Jiangsu Province, China
2. Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210046, Jiangsu Province, China
3. Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, 211166, China - ISSN：1573-7330
文摘
Purpose In this study, we estimated the effect of blastocoele expansion, ICM and TE quality after warming and culture on the rates of clinical pregnancy, live birth and miscarriage in vitrified-warmed single-blastocyst transfer cycle in a Chinese population. Methods A retrospective analysis of 263?cycles of vitrified-warmed single-blastocyst transfers was performed. Results The blastocysts with higher TE grade significantly increased the rates of clinical pregnancy (OR--.59, 95?% CI, 0.35-.99, P--.045, grade (A-?B) vs grade C) and live birth (OR--.55, 95?% CI, 0.32-.94, P--.029, grade (A-?B) vs grade C). And the association between TE grade and the rate of live birth didn’t change after the number of repeated cycles was adjusted (OR--.55, 95?% CI, 0.32-.95, P--.033, grade (A-?B) vs grade C). The number of repeated cycles was a confounding factor significantly different between the live birth and no live birth groups. By contrast, neither blastocoele expansion nor inner cell mass was statistically related to the rates of clinical pregnancy, live birth and miscarriage. Conclusions Our data firstly provided the evidence that TE grading, but not ICM grading, was significantly associated with the clinical pregnancy rate and live birth rate in vitrified-warmed blastocyst transfer cycles in a Chinese population. TE morphology may help predict outcomes of pregnancy in single-blastocyst transfer.