Functional FEN1 genetic variants and haplotypes are associated with glioma risk

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• 作者：Yi-Dong Chen (1)
  Xiaojiao Zhang (2)
  Xiao-Guang Qiu (3)
  Jinpeng Li (4)
  Qipeng Yuan (2)
  Tao Jiang (5)
  Ming Yang (2)
  
• 关键词：FEN1 ; Polymorphism ; Haplotype ; Glioma ; Susceptibility
• 刊名：Journal of Neuro-Oncology
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：111
• 期：2
• 页码：145-151
• 全文大小：203KB
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• 作者单位：Yi-Dong Chen (1)
  Xiaojiao Zhang (2)
  Xiao-Guang Qiu (3)
  Jinpeng Li (4)
  Qipeng Yuan (2)
  Tao Jiang (5)
  Ming Yang (2)
  
  1. Department of Radiation Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
  2. College of Life Science and Technology, Beijing University of Chemical Technology, P. O. Box 53, Beijing, 100029, China
  3. Glioma Institute of Tiantan Hospital, Capital Medical University, Beijing, China
  4. Department of Intervention Surgery, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, Shandong, China
  5. Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, China
  
• ISSN：1573-7373

文摘

As a tumor suppressor, FEN1 plays an essential role in keeping genomic instability and preventing tumorigenesis. There are two functional genetic variants (-9G>A and 4150G>T) in the FEN1 gene, which have been associated with DNA damage levels in coke-oven workers as well as risks of lung cancer, hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer in general populations. However, it is still unknown how these polymorphisms and their haplotypes are associated with glioma risk. Therefore, we investigated the role of these polymorphisms in glioma development using a case–control design in a Chinese population. The impact of the haplotypes constructed by these two polymorphisms on glioma risk was also examined. It was observed that the FEN1-9GG or 4150GG genotype were significantly associated to increased glioma risk compared with the -9AA or 4150TT genotype [Odds ratios (OR)?=?1.87, 95?% confidence interval (CI)?=?1.23?.85, P?=?0.003; or OR?=?1.87, 95?% CI?=?1.23?.84, P?=?0.003). The associations were more pronounced among female subjects (For -9AG or GG genotype: OR?=?2.35, 95?% CI?=?1.22?.52; for 4150TG or GG genotype: OR?=?2.33, 95?% CI?=?1.21?.48) and patients with grade 1 or 2 disease (For -9AG or GG genotype: OR?=?2.21, 95?% CI?=?1.20?.05; for 4150TG or GG genotype: OR?=?2.45, 95?% CI?=?1.31?.58). Additionally, the G?9G4150 haplotype was also significantly associated with increased glioma risk compared with the A?9T4150 haplotype. Our results suggest that FEN1 polymorphisms and haplotypes are associated with glioma risk.