Electroacupuncture reduces myocardial infarct size and improves post-ischemic recovery by invoking release of humoral, dialyzable, cardioprotective factors

详细信息    查看全文

• 作者：Kathrine L. Redington (1)
  Tara Disenhouse (1)
  Jing Li (1)
  Can Wei (1)
  Xiaojing Dai (1)
  Rachel Gladstone (1)
  Cedric Manlhiot (1)
  Andrew N. Redington (1)
  
• 关键词：Remote preconditioning ; Electroacupuncture ; Cardioprotection
• 刊名：The Journal of Physiological Sciences
• 出版年：2013
• 出版时间：May 2013
• 年：2013
• 卷：63
• 期：3
• 页码：219-223
• 全文大小：236KB
• 参考文献：1. Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P (1993) Regional ischemic ‘preconditioning-protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation 87:893 CrossRef
  2. Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R (2002) Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 106:2881-883 CrossRef
  3. Tapuria N, Kumar Y, Habib MM, Abu Amara M, Seifalian AM, Davidson BR (2008) Remote ischemic preconditioning: a novel protective method from ischemia reperfusion injury—a review. J Surg Res 150:304-30 CrossRef
  4. Cheung MM, Kharbanda RK, Jonstantinov IE, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN (2006) Randomised controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery first clinical application in humans. J Am Coll Cardiol 47:2277-282 CrossRef
  5. Shimizu M, Tropak M, Diaz RJ, Suto F, Surendra H, Kuzmin E, Li J, Gross G, Wilson GJ, Callaham J, Redington AN (2009) Transient limb ischemia remotely preconditions through a humoral mechanism acting directly on the myocardium evidence suggesting cross-species protection. Clin Sci 117:191-00 CrossRef
  6. Steensrud T, Li J, Dai X, Manlhiot C, Kharbanda RK, Tropak M, Redington A (2010) Pretreatment with nitric oxide donor SNAP or nerve transection blocks humoral preconditioning by remote limb ischemia or intra-arterial adenosine. Am J Physiol Heart Circ Physiol 299(5):298-03 CrossRef
  7. Redington KL, Disenhouse T, Strantzas SC, Gladstone R, Wei C, Tropack MB, Dai X, Manlhiot C, Li J, Redington AN (2012) Remote cardioprotection by direct peripheral nerve stimulation and topical capsaicin is mediated by circulating humoral factors. Basic Res Cardiol 107(2):241 CrossRef
  8. Gao J, Fu W, Jin Z, Yu X (2006) A preliminary study on the cardioprotection of acupuncture pretreatment in rats with ischemia and reperfusion: involvement of cardiac beta-adrenoceptors. J Physiol Sci. 56(4):275-79 CrossRef
  9. Gao J, Fu W, Jin Z, Yu X (2007) Acupuncture pretreatment protects heart from injury in rats with myocardial ischemia and reperfusion via inhibition of the beta(1)-adrenoceptor signaling pathway. Life Sci 80(16):1484-489
  10. Zhang H, Liu L, Huang G, Zhou L, Wu W, Zhang T, Huang H (2009) Protective effect of electroacupuncture at the Neiguan point in a rabbit model of myocardial ischemia–reperfusion injury. Can J Cardiol 25(6):35-63 CrossRef
  11. Zhou W, Ko Y, Benharash P, Yamakawa K, Patel S, Ajijola OA, Mahajan A (2012) Cardioprotection of electroacupuncture against myocardial ischemia–reperfusion injury by modulation of cardiac norepinephrine release. Am J Physiol Heart Circ Physiol. 302(9):H1818–H1825 CrossRef
  12. Dow J, Painovich J, Hale SL, Tjen-A-Looi S, Longhurst JC, Kloner RA (2012) Absence of actions of commonly used Chinese herbal medicines and electroacupuncture on myocardial infarct size. J Cardiovasc Pharmacol Ther 17(4):403-11 CrossRef
  13. Tsou MT, Huang CH, Chiu JH (2004) Electroacupuncture on PC6 (Neiguan) attenuates ischemia/reperfusion injury in rat hearts. Am J Chin Med 32(6):951-65 CrossRef
  14. Hanouz JL, Zhu L, Persehaye E, Massetti M, Babatasi G, Khayat A, Ducouret P, Plaud B, Gérard JL (2005) Ketamine preconditions isolated human right atrial myocardium: roles of adenosine triphosphate-sensitive potassium channels and adrenoceptors. Anesthesiology 102(6):1190-196 CrossRef
  15. Han J, Kim N, Joo H, Kim E (2002) Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts. Am J Physiol Heart Circ Physiol. 283(1):H13–H21
  16. Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM (2007) Effect of remote ischemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet 370(9587):575-79 CrossRef
  
• 作者单位：Kathrine L. Redington (1)
  Tara Disenhouse (1)
  Jing Li (1)
  Can Wei (1)
  Xiaojing Dai (1)
  Rachel Gladstone (1)
  Cedric Manlhiot (1)
  Andrew N. Redington (1)
  
  1. Division of Cardiology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G1X8, Canada
  
• ISSN：1880-6562

文摘

Previous studies have shown that electroacupuncture (EA) can induce cardioprotection against ischemia–reperfusion (IR) injury, but its mechanisms are incompletely understood. We have previously shown that several other forms of remote preconditioning of the heart work, at least in part, via the release of circulating cardioprotective factors into the bloodstream, that can be dialyzed and subsequently shown to reduce IR injury in isolated hearts. We used the same methods to assess whether EA leads to similar humoral cardioprotection. EA rabbits were subjected to 60?min of bilateral stimulation at the Neiguan point, following which their blood was drawn, dialyzed, and used to perfuse hearts in Langendorff preparation and subsequently subjected to 60?min of global ischemia and 120?min of reperfusion. Compared to controls, dialysate from EA animals led to significant reduction in infarct size and improved functional recovery. The degree of cardioprotection was no different to that seen in animals randomized to receive remote preconditioning using transient limb ischemia (4 cycles of 5?min ischemia/5?min reperfusion). These results suggest that EA recapitulates the cardioprotection achieved by remote preconditioning, by similarly leading to release of circulating cardioprotective factors.