The rate of glycolysis quantitatively mediates specific histone acetylation sites
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- 作者：Ahmad A. Cluntun ; He Huang ; Lunzhi Dai ; Xiaojing Liu ; Yingming Zhao…
- 关键词：Acetyl coenzyme A (acetyl ; CoA) ; Histone acetylation ; Warburg effect ; Glycolysis ; Cancer
- 刊名：Cancer & Metabolism
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：3
- 期：1
- 全文大小：1,455 KB
- 刊物主题：Cancer Research; Oncology; Metabolomics; Metabolic Diseases; Imaging / Radiology; Cell Biology;
- 出版者：BioMed Central
- ISSN：2049-3002
文摘
Background Glucose metabolism links metabolic status to protein acetylation. However, it remains poorly understood to what extent do features of glucose metabolism contribute to protein acetylation and whether the process can be dynamically and quantitatively regulated by differing rates of glycolysis.