Cancer risks and long-term community-level exposure to pentachlorophenol in contaminated areas, China
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- 作者：Pan Cheng ; Qinghe Zhang ; Xiaomei Shan…
- 关键词：Pentachlorophenol ; Cancer risk ; General population ; Community ; level ; Ecological design ; Drinking water
- 刊名：Environmental Science and Pollution Research
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：22
- 期：2
- 页码：1309-1317
- 全文大小：654 KB
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- 刊物主题：Environment
Environment
Atmospheric Protection, Air Quality Control and Air Pollution
Waste Water Technology, Water Pollution Control, Water Management and Aquatic Pollution
Industrial Pollution Prevention - 出版者：Springer Berlin / Heidelberg
- ISSN：1614-7499
文摘
Widespread use of pentachlorophenol (PCP) in schistosomiasis endemic areas had led to ubiquitous exposure to PCP and its residues. Numerous studies had revealed that occupational PCP exposure probably increased risk of cancers, but whether long-term community-level exposure to PCP generates the similarly carcinogenic effect, seldom studies focused on it. This study was to explore the cancer risks of long-term community-level PCP exposure from drinking water in a Chinese general population. Incident (2009-012) cancer records were identified by local government national registry. And PCP concentration of raw drinking water samples in each district was measured by GC-MS/MS analysis for further division of three PCP exposure categories by interquartile range (high vs. medium vs. low). Internal comparisons were performed, and standard rate ratio was calculated to describe the relationship between PCP exposure and cancer risks by using low-exposure group as the reference group. PCP was detected in all 27 raw drinking water samples ranging from 11.21 to 684.00?ng/L. A total of 6,750 cases (4,409 male and 2,341 female cases) were identified, and age-standardized rate (world) was 154.95 per 100,000 person-years. The cancer incidence for the high-exposure group was remarkably high. Internal comparisons indicated that high PCP exposure might be positively associated with high cancer risks in the community population, particularly for leukemia (SRR--.93, 95?% CI--.24-.71), maligant lymphoma (SRR--.27, 95?% CI--.10-.54), and esophageal cancer (SRR--.42, 95?% CI--.35-.50). Long-term community-level exposure to PCP was probably associated with hemolymph neoplasm, neurologic tumors, and digestive system neoplasm.