Genotypic analysis and latent membrane protein 1 expression of Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients

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• 作者：Haijuan Wang ; Hui Li ; Xiaoming Xing ; Chengquan Zhao ; Bing Luo
• 关键词：Extranodal NK/T ; cell lymphoma ; Nasal type ; EBV ; Genotypes ; LMP1
• 刊名：Archives of Virology
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：160
• 期：8
• 页码：2071-2074
• 全文大小：545 KB
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• 作者单位：Haijuan Wang (1)
  Hui Li (2)
  Xiaoming Xing (3)
  Chengquan Zhao (4)
  Bing Luo (1)
  
  1. Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao, 266021, China
  2. Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao, 266003, China
  3. Department of Pathology Laboratory, The Affiliated Hospital of Qingdao University Medical College, 16 Jiangsu Road, Qingdao, 266003, China
  4. Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798

文摘

As the most common NK/T-cell lymphoma in Asian countries, extranodal NK/T-cell lymphoma, nasal type (ENKTL), has unique clinical features and a strong association with Epstein-Barr virus (EBV). In order to gain a preliminary understanding of the relationship between ENKTL and EBV, we performed genotypic analysis of EBV and investigated LMP1 expression in extranodal NK/T-cell lymphoma. Our study shows that ENKTL is an EBV-associated malignancy and that A, C and F are the predominant EBV genotypes in northern China. LMP1 expression is stronger in extranasal sites than nasal sites, and the expression level is strongly correlated to ENKTL and may play an important role in the development of ENKTL.