The influence of positive selection and trans-species evolution on DPB diversity in the golden snub-nosed monkeys (Rhinopithecus roxellana)

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• 作者：Xiaoyue Song ; Pei Zhang ; Kang Huang ; Dan Chen ; Songtao Guo ; Xiaoguang Qi…
• 关键词：MHC ; Rhinopithecus roxellana ; Positive selection ; Trans ; species polymorphism ; Genetic diversity
• 刊名：Primates
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：57
• 期：4
• 页码：489-499
• 全文大小：623 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Zoology
  Animal Ecology
  Behavioural Sciences
  Evolutionary Biology
  
• 出版者：Springer Japan
• ISSN：1610-7365
• 卷排序：57

文摘

Genetic variation plays a significant role in the adaptive potential of the endangered species. The variation at major histocompatibility complex (MHC) genes can offer valuable information on selective pressure related to natural selection and environmental adaptation, particularly the ability of a host to continuously resist evolving parasites. Thus, the genetic polymorphism on exon 2 of the MHC DPB1 gene in the golden snub-nosed monkeys (Rhinopithecus roxellana) was specifically analyzed. The results show that the 6 Rhro-DPB1 alleles identified from 87 individuals exhibit positive selection and trans-species polymorphism. The results also imply that although the populations of the species have experienced dramatic reduction and severe habitat fragmentation in recent Chinese history, balancing selection still maintains relatively consistent, with moderate DPB1 polymorphism. Thus, the study provides valuable information and evidence in developing effective strategies and tactics for genetic health and population size expansion of the species. It also offers strong genetic background for further studies on other primate species, particularly those in Rhinopithecus—a further endeavor that would result in fully understanding the MHC genetic information of the Asian colobines.