Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease risk
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- 作者：Xu Han ; Lixuan Gui ; Bing Liu ; Jing Wang ; Yaru Li ; Xiayun Dai ; Jun Li…
- 关键词：Coronary heart disease ; Uric acid ; Polymorphism ; Gene ; environment interaction
- 刊名：BMC Genetics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：16
- 期：1
- 全文大小：375 KB
- 参考文献：1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics-013 update: a report from the American Heart Association. Circulation. 2013;127(1):e6–e245. CrossRef
2. Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, et al. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population. Nat Genet. 2011;43(4):345-. CrossRef
3. Gustavsson J, Mehlig K, Leander K, Strandhagen E, Bjorck L, Thelle DS, et al. Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women. Atherosclerosis. 2012;220(2):486-2. CrossRef
4. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum. 2009;61(2):225-2. CrossRef
5. Kathiresan S, Altschuler D, Anand S, Ardissino D, Asselta R, Ball SG, et al. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009;41(3):334-1. CrossRef
6. Fievet C, Nuttens MC, Ducimetiere P, Fruchart JC, Bertrand M, Salomez JL. Relation of arteriographically defined coronary artery disease to serum lipoprotein particles mapped with monoclonal antibodies. Circulation. 1991;84(1):153-. CrossRef
7. Sundell J, Raitakari OT, Viikari J, Kantola I, Nuutila P, Knuuti J. Both BMI and waist circumference are associated with coronary vasoreactivity in overweight and obese men. Obes Facts. 2012;5(5):693-. CrossRef
8. Dehghan A, Kottgen A, Yang Q, Hwang S, Kao W, Rivadeneira F, et al. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008;372(9654):1953-1. CrossRef
9. Avram Z, Krishnan E. Hyperuricaemia–where nephrology meets rheumatology. Rheumatology. 2008;47(7):960-. CrossRef
10. Tamba S, Nishizawa H, Funahashi T, Okauchi Y, Ogawa T, Noguchi M, et al. Relationship between the Serum Uric Acid Level, Visceral Fat Accumulation and Serum Adiponectin Concentration in Japanese Men. Intern Med. 2008;47(13):1175-0. CrossRef
11. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, et al. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003;41(6):1287-3. CrossRef
12. Stark K, Reinhard W, Grassl M, Erdmann J, Schunkert H, Illig T, et al. Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. PLoS ONE. 2009;4(11):e7729. CrossRef
13. Smith GD, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol. 2004;33(1):30-2. CrossRef
14. Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013;99(11):759-6. CrossRef
15. Kivity S, Kopel E, Maor E, Abu-Bachar F, Segev S, Sidi Y, et al. Association of serum uric acid and cardiovascular disease in healthy adults. Am J Cardiol. 2013;111(8):1146-1.
文摘
Background Multiple studies investigated the associations between serum uric acid and coronary heart disease (CHD) risk. However, further investigations still remain to be carried out to determine whether there exists a causal relationship between them. We aim to explore the associations between genetic variants in uric acid related loci of SLC2A9 and ABCG2 and CHD risk in a Chinese population. Results A case–control study including 1,146 CHD cases and 1,146 controls was conducted. Association analysis between two uric acid related variants (SNP rs11722228 in SLC2A9 and rs4148152 in ABCG2) and CHD risk was performed by logistic regression model. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Compared with subjects with A allele of rs4148152, those with G allele had a decreased CHD risk and the association remained significant in a multivariate model. However, it altered to null when BMI was added into the model. No significant association was observed between rs11722228 and CHD risk. The distribution of CHD risk factors was not significantly different among different genotypes of both SNPs. Among subjects who did not consume alcohol, the G allele of rs4148152 showed a moderate protective effect. However, no significant interactions were observed between SNP by CHD risk factors on CHD risk. Conclusions There might be no association between the two uric acid related SNPs with CHD risk. Further studies were warranted to validate these results.