Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave
详细信息 查看全文
- 作者：Geng Li (1)
Jie-Ming Liang (2)
Pei-Wen Li (4)
Xiaoqiang Yao (5)
Peter Zhong Pei (6)
Wei Li (6)
Qi-Hua He (7)
Xifei Yang (8)
Queenie C. C. Chan (9)
Paul Y. S. Cheung (3)
Qi Yuan Ma (1)
Siu Kam Lam (3)
Patrick Y. C. Cheng (3)
Edward S. Yang (1) (10) (3) (4) - 关键词：Acupuncture ; Acoustic wave ; MRE ; Ca2+ ion channel ; Human ; Mice ; Fibroblast ; Endothelial cells
- 刊名：Pfl眉gers Archiv - European Journal of Physiology
- 出版年：2011
- 出版时间：October 2011
- 年：2011
- 卷：462
- 期：4
- 页码：587-597
- 全文大小：697KB
- 参考文献：1. Auld BA (1990) Acoustic fields and waves in solid. Krieger, Melbourne
2. Berridge MJ, Irvine RF (1989) Inositol phosphates and cell signalling. Nature 341:197-05 CrossRef
3. Chan QCC, Li G, Ehman RL, Grimm RC, Li R, Yang ES (2006) Needle shear wave driver for magnetic resonance elastography. Magn Reson Med 55:1175-179 CrossRef
4. Diener HC et al (2006) Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomized controlled clinical trial. Lancet Neurol 5:310-16 CrossRef
5. Dresner MA et al (2001) Magnetic resonance elastography of skeletal muscle. J Magn Reson Imaging 13:269-76 CrossRef
6. Duck FA (1990) Physical properties of tissue: a comprehensive reference book. Academic, London
7. Endres HG et al (2007) Acupuncture for the treatment of chronic knee and back pain. Dtsch Arztebl 104:A123–A130
8. Falcke M (2004) Reading the patterns in living cells—the physics of Ca2+ signaling. Adv Phys 53:255-40 CrossRef
9. Jacob R et al (1988) Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells. Nature 335:40-5 CrossRef
10. Kinsler LE, Frey AR, Coppens AB, Sanders JV (1990) Fundamentals of acoustics. Wiley, New York
11. Kong J et al (2007) Test–retest study of fMRI signal change evoked by electroacupuncture stimulation. NeuroImage 34:171-181 CrossRef
12. Langevin HM et al (2004) Tissue displacements during acupuncture using ultrasound elastography techniques. Ultrasound Med Biol 30:1173-183 CrossRef
13. Li G et al (2006) An fMRI study of somatosensory-implicated acupuncture points in stable somatosensory stroke patients. J Magn Reson Imaging 24:1018-024 CrossRef
14. Linde K et al (2005) Acupuncture for patients with migraine. JAMA 293:2118-125 CrossRef
15. Lu GD, Needham J (1980) Celestial lancets: a history and rationale of acupuncture and moxibustion. Cambridge University Press, Cambridge, UK
16. Muthupillai R et al (1995) Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science 269(5232):1854-857 CrossRef
17. Politi A, Gaspers LD, Thomas AP, Hofer T (2006) Models of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedback. Biophys J 90:3120-133 CrossRef
18. Rudolf R et al (2004) In vivo monitoring of Ca2+ uptake into mitochondria of mouse skeletal muscle during contraction. J Cell Biol 166:527-36 CrossRef
19. Sinkus R et al (2005) Imaging anisotropic and viscous properties of breast tissue by magnetic resonance elastrography. Magn Reson Med 53:273-87 CrossRef
20. Stux G, Berman B, Pomeranz B (2003) Basics of acupuncture. Springer, Berlin CrossRef
21. Tallini YN et al (2006) Imaging cellular signals in the heart in vivo: cardiac expression of the high-signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci USA 103:4753-758 CrossRef
22. Tsien RW, Tsien RY (1990) Calcium channels, stores and oscillations. Annu Rev Cell Biol 6:715-602 CrossRef
23. Witt C et al (2005) Acupuncture in patients with osteoarthritis of the knee: a randomized trial. Lancet 366:136-43 CrossRef - 作者单位：Geng Li (1)
Jie-Ming Liang (2)
Pei-Wen Li (4)
Xiaoqiang Yao (5)
Peter Zhong Pei (6)
Wei Li (6)
Qi-Hua He (7)
Xifei Yang (8)
Queenie C. C. Chan (9)
Paul Y. S. Cheung (3)
Qi Yuan Ma (1)
Siu Kam Lam (3)
Patrick Y. C. Cheng (3)
Edward S. Yang (1) (10) (3) (4)
1. Time Medical Systems, No. 2, Science Park West Avenue, Hong Kong, China
2. Biomedical Engineering, The University of Hong Kong, Hong Kong, China
4. EE Department, National Central University, Chungli, Taiwan
5. School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China
6. Department Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
7. Health Science Center, Peking University, Beijing, China
8. Shenzhen Center for Disease Control and Prevention, Shenzhen, China
9. Philips Electronics HK Ltd, Science Park, Hong Kong, China
3. The University of Hong Kong, Hong Kong, China
10. Columbia University, New York, NY, USA - ISSN：1432-2013
文摘
This article presents a novel model of acupuncture physiology based on cellular calcium activation by an acoustic shear wave (ASW) generated by the mechanical movement of the needle. An acupuncture needle was driven by a piezoelectric transducer at 100?Hz or below, and the ASW in human calf was imaged by magnetic resonance elastography. At the cell level, the ASW activated intracellular Ca2+ transients and oscillations in fibroblasts and endothelial, ventricular myocytes and neuronal PC-12 cells along with frequency–amplitude tuning and memory capabilities. Monitoring in vivo mammalian experiments with ASW, enhancement of endorphin in blood plasma and blocking by Gd3+ were observed; and increased Ca2+ fluorescence in mouse hind leg muscle was imaged by two-photon microscopy. In contrast with traditional acupuncture models, the signal source is derived from the total acoustic energy. ASW signaling makes use of the anisotropy of elasticity of tissues as its waveguides for transmission and that cell activation is not based on the nervous system.