Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

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• 作者：David J. Bonda (1)
  Xinglong Wang (1)
  Hyoung-Gon Lee (1)
  Mark A. Smith (1)
  George Perry (1) (2)
  Xiongwei Zhu (1)
  
• 关键词：Alzheimer’s disease ; amyloid ; beta ; free radicals ; mitochondria ; mitochondrial dynamics ; oxidative stress
• 刊名：Neuroscience Bulletin
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：30
• 期：2
• 页码：243-252
• 全文大小：255 KB
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• 作者单位：David J. Bonda (1)
  Xinglong Wang (1)
  Hyoung-Gon Lee (1)
  Mark A. Smith (1)
  George Perry (1) (2)
  Xiongwei Zhu (1)
  
  1. Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
  2. UTSA Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, Texas, USA
  
• ISSN：1995-8218

文摘

Considerable debate and controversy surround the cause(s) of Alzheimer’s disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.