Bioactive Lipids-Based pH Sensitive Micelles for Co-Delivery of Doxorubicin and Ceramide to Overcome Multidrug Resistance in Leukemia

详细信息    查看全文

• 作者：Yongzhong Wang (1) (2)
  Yunfei Ding (3)
  Ziming Liu (4)
  Xingrong Liu (3)
  Li Chen (1)
  Weili Yan (3)
  
• 关键词：ceramide ; doxorubicin ; leukemia ; micelle ; oxidized phospholipid
• 刊名：Pharmaceutical Research
• 出版年：2013
• 出版时间：November 2013
• 年：2013
• 卷：30
• 期：11
• 页码：2902-2916
• 全文大小：1236KB
• 参考文献：1. Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008;9(2):139鈥?0. CrossRef
  2. Angel I, Bar A, Haring R. Bioactive lipids and their receptors. Curr Opin Drug Discov Dev. 2002;5(5):728鈥?0.
  3. Ekiz HA, Baran Y. Therapeutic applications of bioactive sphingolipids in hematological malignancies. Int J Cancer. 2010;127(7):1497鈥?06. CrossRef
  4. Fruhwirth GO, Loidl A, Hermetter A. Oxidized phospholipids: from molecular properties to disease. Biochim Biophys Acta. 2007;1772(7):718鈥?6. CrossRef
  5. Bochkov VN, Oskolkova OV, Birukov KG, Levonen AL, Binder CJ, Stockl J. Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal. 2010;12(8):1009鈥?9. CrossRef
  6. Wang Y, Chen L, Ding Y, Yan W. Oxidized phospholipid based pH sensitive micelles for delivery of anthracyclines to resistant leukemia cells / in vitro. Int J Pharmaceut. 2012;422(1鈥?):409鈥?7. CrossRef
  7. Chen R, Feldstein AE, McIntyre TM. Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL. J Biol Chem. 2009;284(39):26297鈥?08. CrossRef
  8. Chen R, Yang L, McIntyre TM. Cytotoxic phospholipid oxidation products. Cell death from mitochondrial damage and the intrinsic caspase cascade. J Biol Chem. 2007;282(34):24842鈥?0. CrossRef
  9. Huang WC, Chen CL, Lin YS, Lin CF. Apoptotic sphingolipid ceramide in cancer therapy. J Lipids. 2011;2011:565316.
  10. Ekiz HA, Baran Y. Bioactive sphingolipids in response to chemotherapy: a scope on leukemias. Anti Cancer Agents Med Chem. 2011;11(4):385鈥?7. CrossRef
  11. van Vlerken LE, Duan Z, Seiden MV, Amiji MM. Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer. Cancer Res. 2007;67(10):4843鈥?0. CrossRef
  12. Liu YY, Yu JY, Yin D, Patwardhan GA, Gupta V, Hirabayashi Y, / et al. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 2008;22(7):2541鈥?1. CrossRef
  13. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 1995;82(3):405鈥?4. CrossRef
  14. Ma P, Dong X, Swadley CL, Gupte A, Leggas M, Ledebur HC, / et al. Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia. J Biomed Nanotechnol. 2009;5(2):151鈥?1. CrossRef
  15. Radin NS. Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? Eur J Biochem. 2001;268(2):193鈥?04. CrossRef
  16. Tagaram HR, Divittore NA, Barth BM, Kaiser JM, Avella D, Kimchi ET, / et al. Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma. Gut. 2011;60(5):695鈥?01. CrossRef
  17. Liu X, Ryland L, Yang J, Liao A, Aliaga C, Watts R, / et al. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Blood. 2010;116(20):4192鈥?01. CrossRef
  18. van Lummel M, van Blitterswijk WJ, Vink SR, Veldman RJ, van der Valk MA, Schipper D, / et al. Enriching lipid nanovesicles with short-chain glucosylceramide improves doxorubicin delivery and efficacy in solid tumors. FASEB J. 2011;25(1):280鈥?. CrossRef
  19. Devalapally H, Duan Z, Seiden MV, Amiji MM. Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles. Clin Cancer Res. 2008;14(10):3193鈥?03. CrossRef
  20. Pande AH, Kar S, Tripathy RK. Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids. Biochim Biophys Acta. 2010;1798(3):442鈥?2. CrossRef
  21. Alakhov V, Klinski E, Li SM, Pietrzynski G, Venne A, Batrakova E, / et al. Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials. Colloids Surf B. 1999;16(1鈥?):113鈥?4. CrossRef
  22. Taha TA, Mullen TD, Obeid LM. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim Biophys Acta. 2006;1758(12):2027鈥?6. CrossRef
  23. Rizvi F, Heimann T, Herrnreiter A, O鈥橞rien WJ. Mitochondrial dysfunction links ceramide activated HRK expression and cell death. PLoS One. 2011;6(3):e18137. CrossRef
  24. Romsicki Y, Sharom FJ. The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter. Biochemistry. 1999;38(21):6887鈥?6. CrossRef
  25. Sachs-Barrable K, Thamboo A, Lee SD, Wasan KM. Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells. J Pharm Pharm Sci. 2007;10(3):319鈥?1.
  
• 作者单位：Yongzhong Wang (1) (2)
  Yunfei Ding (3)
  Ziming Liu (4)
  Xingrong Liu (3)
  Li Chen (1)
  Weili Yan (3)
  
  1. Department of Pharmacal Sciences Harrison School of Pharmacy, Auburn University, Auburn, Alabama, 36849, USA
  2. School of Life Sciences, Anhui University, Hefei, 230039, China
  3. College of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, 610031, China
  4. West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China
  
• ISSN：1573-904X

文摘