Synthesis and biological evaluation of novel 2-(substituted isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles

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• 作者：Feng Liu (1)
  Meiyan Wang (2)
  Xinhuan Teng (1)
  Peizhi Zhang (2)
  Lin Jiang (2)
  
• 关键词：1 ; 3 ; 4 ; Oxadiazole ; Isoxazole ; Synthesis ; Antifungal activity
• 刊名：Research on Chemical Intermediates
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：40
• 期：4
• 页码：1575-1581
• 全文大小：243 KB
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• 作者单位：Feng Liu (1)
  Meiyan Wang (2)
  Xinhuan Teng (1)
  Peizhi Zhang (2)
  Lin Jiang (2)
  
  1. College of Plant Protection, Shandong Agricultural University, Tai鈥檃n, 271018, China
  2. College of Chemistry and Material Science, Shandong Agricultural University, Tai鈥檃n, 271018, China
  
• ISSN：1568-5675

文摘

A series of 2-(5-methyl-3-(4-chloro/trifluoromethylphenyl)isoxazol-4-yl)-5-arylamino-1,3,4-oxadiazoles were synthesized from 4-chloro/trifluoromethyl benzaldehyde, ethyl acetoacetate, hydroxylamine hydrochloride, hydrazine hydrate, and aryl isocyanate by multi-step reactions. The structures of the target compounds were elucidated by IR, 1H NMR, MS, and elemental analysis. All these compounds were tested for in vitro antifungal activities against Botrytis cinerea and Rhizoctonia cerealis by the mycelium growth rate method, and the results indicated that some compounds displayed high antifungal activity against Botrytis cinerea.