Long noncoding RNA HOTAIR involvement in cancer

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• 作者：Yansheng Wu (1) (4)
  Li Zhang (6) (7)
  Yang Wang (3) (4) (5)
  Hui Li (3) (4) (5)
  Xiubao Ren (2) (3) (4) (5)
  Feng Wei (3) (4) (5)
  Wenwen Yu (3) (4) (5)
  Xudong Wang (1) (4)
  Lun Zhang (1) (4)
  Jinpu Yu (3) (4) (5)
  Xishan Hao (3) (4) (5)
  
• 关键词：Noncoding RNA ; HOTAIR ; Cancer ; Metastasis ; Gene regulation
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：35
• 期：10
• 页码：9531-9538
• 全文大小：259 KB
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• 作者单位：Yansheng Wu (1) (4)
  Li Zhang (6) (7)
  Yang Wang (3) (4) (5)
  Hui Li (3) (4) (5)
  Xiubao Ren (2) (3) (4) (5)
  Feng Wei (3) (4) (5)
  Wenwen Yu (3) (4) (5)
  Xudong Wang (1) (4)
  Lun Zhang (1) (4)
  Jinpu Yu (3) (4) (5)
  Xishan Hao (3) (4) (5)
  
  1. Department of Maxillofacial and Otorhinolaryngology Head & Neck Surgery, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People鈥檚 Republic of China
  4. National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People鈥檚 Republic of China
  6. Department of Breast Cancer Medical Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People鈥檚 Republic of China
  7. Key Laboratory of Cancer Prevention and Therapy, Tianjin, People鈥檚 Republic of China
  3. Biotherapy Center, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People鈥檚 Republic of China
  5. Key Laboratory of Cancer Immunology and Biotherapy, Tianjin, People鈥檚 Republic of China
  2. Department of Immunology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People鈥檚 Republic of China
  
• ISSN：1423-0380

文摘

Evidences have been provided that long noncoding RNAs (lncRNAs) act as key molecules in epigenetic regulation and are involved in the development process of cancer in recent studies. HOX transcript antisense RNA (HOTAIR), a long intergenic noncoding RNA (lincRNA), functions as a molecular scaffold to link and target two histone modification complexes PRC2 and LSD1, then reprograms chromatin states by couples histone H3K27 methylation and H3K4 demethylation for epigenetic gene silencing to promote cancer metastasis. HOTAIR, regarded as an oncogene, is pervasively overexpressed in most solid cancers and correlated with tumor invasion, progression, metastasis, and poor prognosis, and HOTAIR has been proven to play a critical role in most biological process of cancer and would be a potential new target in cancer therapy.