Investigation on phase-coded third harmonic imaging for normal and pathological tissues in transmission mode in vitro

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• 作者：Qingyu Ma (1) (2)
  Xiufen Gong (1)
  Dong Zhang (1)
  Yong Ma (1)
  
• 关键词：phase ; coded technique ; third order harmonic enhancement ; pathological tissues ; imaging in transmission mode
• 刊名：Chinese Science Bulletin
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：51
• 期：10
• 页码：1180-1184
• 全文大小：3589KB
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• 作者单位：Qingyu Ma (1) (2)
  Xiufen Gong (1)
  Dong Zhang (1)
  Yong Ma (1)
  
  1. State Key Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, 210093, China
  2. Education Technique Department, Nanjing Normal University, Nanjing, 210097, China
  
• ISSN：1861-9541

文摘

In this paper, a phase-coded pulse technique is proposed to improve the signal-to-noise ratio (SNR) in the 3rd harmonic imaging in transmission mode, where three pulses with initial phases of 0°, 120° and 240° are transmitted and their corresponding received signals are linearly summed. By means of simulations and measurements, we show that the 3rd harmonic is enhanced by 9.5 dB, whereas the fundamental or the 2nd harmonic components are suppressed; the axial and lateral beam profiles of the processed 3rd harmonics are superior to those of the fundamental or 2nd harmonic components. In addition, this technique is applied to obtain the 3rd harmonic images for two normal and pathological biological tissues in transmission mode. This technique yields a dramatically cleaner and sharper contrast than the images obtained by the traditional fundamental imaging and the 2nd harmonic imaging, which helps distinguish the normal and pathological states of tissues.