Chemo-enzymatic Synthesis of Novel β-Hydroxy-β-methylbutryric Acid (HMB)–Medium Chain Triacylglycerol (MCT) Complexes

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• 作者：Ling-Zhi Cheong (1)
  Katarzyna Widzisz (1)
  Yingyao Wang (1) (2)
  Henrik Helligs? Jensen (3)
  Peter Kappel Theil (4)
  Zheng Guo (1)
  Xuebing Xu (1)
  
• 刊名：Journal of the American Oil Chemists' Society
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：90
• 期：6
• 页码：919-922
• 全文大小：246KB
• 参考文献：1. Hao Y, Jackson JR, Wang Y, Edens N, Pereira SL, Alway SE (2011) Beta-Hydroxy-beta-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. Am J Physiol 301(3):701-15
  2. Aversa Z, Bonetto A, Costelli P, Minero VG, Penna F, Baccino FM, Lucia S, Rossi Fanelli F, Muscaritoli M (2011) Beta-hydroxy-beta-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. Int J Oncol 38(3):713-20
  3. Alon T, Bagchi D, Preuss HG (2002) Supplementing with beta-hydroxy-beta-methylbutyrate (HMB) to build and maintain muscle mass: a review. Res Commun Mol Pathol Pharmacol 111:139-51
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  5. Tsuji H, Kasai M, Takeuchi H, Nakamura M, Okazaki M, Kondo K (2001) Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. J Nutr 131(11):2853-859
  6. Hansen AV, Lauridsen C, S?rensen MT, Bach Knudsen KE, Thiel PK (2012) Effects of nutrient supply, plasma metabolites and nutritional status of sows during transition on performance in the next lactation. J Anim Sci 90(2):466-80 CrossRef
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• 作者单位：Ling-Zhi Cheong (1)
  Katarzyna Widzisz (1)
  Yingyao Wang (1) (2)
  Henrik Helligs? Jensen (3)
  Peter Kappel Theil (4)
  Zheng Guo (1)
  Xuebing Xu (1)
  
  1. Department of Engineering, Aarhus University, 8000, Aarhus, Denmark
  2. Academy of State Administration of Grain, Beijing, China
  3. Department of Chemistry, Aarhus University, 8000, Aarhus, Denmark
  4. Department of Animal Science, Aarhus University, 8830, Tjele, Denmark
  
• ISSN：1558-9331

文摘

β-Hydroxy-β-methylbutyrate (HMB) is reported to have ergogenic benefits such as reducing muscle wasting, promoting exercise performance and skeletal muscle hypertrophy. When used as a dietary feed, it has been found to improve colostral milk fat and the growth of piglets. Medium chain triacylglycerols (MCT) are a good energy source as they can be subjected to β-oxidation in the liver without being stored as fats. When used as animal feed, HMB–MCT complexes are reported to stimulate growth and produce leaner meat product. A high yield two-steps chemo-enzymatic pathway for synthesis of HMB–MCT complexes has been developed. Ethyl HMB ester was first synthesized using a chemical catalyst. Following that, it was transesterified with MCT by using a biocatalyst. Approximately 85?wt% of HMB–MCT complexes can be achieved using this two-step synthetic pathway. The reaction mechanism and some of the reaction parameters were also briefly elucidated.