Enhancement of Membrane B7-H3 Costimulatory Molecule but Reduction of Its Soluble Form in Multiple Sclerosis

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• 作者：Juean Jiang (1) (3)
  Jianhua Jiang (4)
  Cuiping Liu (2)
  Guangbo Zhang (2)
  Li Gao (1)
  Yongjing Chen (1)
  Ranran Zhu (1)
  Ting Wang (1)
  Fengmin Wang (1) (5)
  Xueguang Zhang (1) (2)
  Qun Xue (4)
  
• 关键词：Multiple sclerosis ; B7 ; H3 ; autoreactive T cell ; immunoregulation
• 刊名：Journal of Clinical Immunology
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：33
• 期：1
• 页码：118-126
• 全文大小：329KB
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• 作者单位：Juean Jiang (1) (3)
  Jianhua Jiang (4)
  Cuiping Liu (2)
  Guangbo Zhang (2)
  Li Gao (1)
  Yongjing Chen (1)
  Ranran Zhu (1)
  Ting Wang (1)
  Fengmin Wang (1) (5)
  Xueguang Zhang (1) (2)
  Qun Xue (4)
  
  1. Institute of Medical Biotechnology, Medical College of Soochow University, Suzhou, Jiangsu, 215007, China
  3. Department of Special Requirements Ward, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China
  4. Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China
  2. Jiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, No.708 Renmin Road, Suzhou, Jiangsu, 215007, China
  5. Testing Center, Center for Disease Prevention and Control, Changzhou, Jiangsu, 213000, China
  
• ISSN：1573-2592

文摘

Purpose Multiple sclerosis (MS) is an autoimmune disease of the central nervous system mediated by T cells. B7-H3 plays a diverse role in regulating T cell responses. However, its expression and clinical significance in MS are not well known. This study analyzed the expression of membrane B7-H3 (mB7-H3) and levels of soluble B7-H3 (sB7-H3) in MS patients to determine its clinical significance. Methods Peripheral blood (PB) or cerebrospinal fluid (CSF) samples from healthy controls, other noninflammatory neurological disorders, viral encephalitis, and MS patients were collected. Expression of mB7-H3 on immune cells was detected by flow cytometry. Levels of sB7-H3 in serum or CSF samples were measured by ELISA. Results mB7-H3 expression was up-regulated in CSF from MS patients compared to PB (p-lt;-.001). However, serum or CSF levels of sB7-H3 in MS patients were significantly lower than those in controls (p-lt;-.05). Relapsing-MS patients had higher CSF mB7-H3 expression than the remitting subgroup. Relapsing-MS patients had decreased serum and CSF sB7-H3 levels compared with the remitting subgroup. Neurological deficits showed negative correlations with serum or CSF sB7-H3 levels, but a positive correlation with CSF mB7-H3 expression. Methylprednisolone therapy significantly elevated sB7-H3 levels and reduced mB7-H3 expression compared with pre-therapy levels. sB7-H3 levels did not correlate with mB7-H3 expression. Conclusions We demonstrated enhanced mB7-H3 expression and reduced sB7-H3 levels in MS patients which correlated with the clinical characteristics of MS patients. These results suggest that B7-H3 may be a promising biomarker and associated with the pathogenesis of MS.