Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling

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• 作者：Chunyan Sun ; Meixia Zhang ; Xiaolei Shan ; Xueying Zhou ; Jiao Yang ; Yanli Wang ; Jesse Li-Ling and Yihui Deng
• 关键词：Cucurbitacin E ; p53 ; PANC ; 1 ; Pancreatic cancer ; STAT3
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2010
• 出版时间：April, 2010
• 年：2010
• 卷：136
• 期：4
• 页码：603-610
• 全文大小：735.8 KB

文摘

Purpose Pancreatic cancer has been a serious disease worldwide for its high mortality. Cucurbitacin E is a member of triterpenoid family isolated from plants showing antiproliferative activity on various cancer cells. In this study, we have explored whether cucurbitacin E also has an anti-tumor effect on pancreatic cancer cells.