Glycan microarrays of fluorescently-tagged natural glycans

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• 作者：Xuezheng Song ; Jamie Heimburg-Molinaro ; David F. Smith…
• 关键词：Functional Glycomics ; Glycans ; Glycan microarray ; Shotgun glycomics ; Natural glycans
• 刊名：Glycoconjugate Journal
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：32
• 期：7
• 页码：465-473
• 全文大小：886 KB
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  27.Palma, A.S., Feizi, T., Childs, R.A., Chai
• 作者单位：Xuezheng Song (1) (2)
  Jamie Heimburg-Molinaro (1) (2)
  David F. Smith (1) (2)
  Richard D. Cummings (1) (2)
  
  1. Department of Biochemistry, The National Center for Functional Glycomics, Emory University School of Medicine, Atlanta, GA, 30322, USA
  2. Department of Biochemistry, O. Wayne Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Suite 4025, Atlanta, GA, 30322, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-4986

文摘

This review discusses the challenges facing research in ‘functional glycomics-and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be captured from their natural sources, isolated and fluorescently-tagged for detailed structural analysis and for presentation on glycan microarrays for functional recognition by glycan-binding proteins. These advances in glycan preparation and manipulation enable the streamlining of functional glycomics studies and will help to propel the field forward in studying natural, biologically relevant glycans. Keywords Functional Glycomics Glycans Glycan microarray Shotgun glycomics Natural glycans