Determination of volatile organic compounds including alcohols in refill fluids and cartridges of electronic cigarettes by headspace solid-phase micro extraction and gas chromatography–mass spectrometry

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• 作者：Hyun-Hee Lim ; Ho-Sang Shin
• 关键词：Volatile organic compounds ; Electronic cigarette refill fluids ; Headspace solid ; phase micro extraction ; Gas chromatography–mass spectrometry
• 刊名：Analytical and Bioanalytical Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：409
• 期：5
• 页码：1247-1256
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Analytical Chemistry; Biochemistry, general; Laboratory Medicine; Characterization and Evaluation of Materials; Food Science; Monitoring/Environmental Analysis;
• 出版者：Springer Berlin Heidelberg
• ISSN：1618-2650
• 卷排序：409

文摘

An analytical method for the detection of 14 volatile organic compounds (VOCs) was developed to investigate VOCs in refill fluids and cartridges of electronic cigarettes (EC) using headspace solid-phase micro extraction (HS-SPME) coupled with gas chromatography–mass spectrometry (GC–MS). In total, 14 VOCs were identified and quantified in 283 flavored liquids, 21 nicotine liquids, and 12 disposable cartridges. The detected concentration ranges of the VOCs are as follows: benzene (0.008–2.28 mg L−1), toluene (0.006–0.687 mg L−1), ethylbenzene (0.01–1.21 mg L−1), m-xylene (0.002–1.13 mg L−1), p-xylene (0.007–2.8 mg L−1), o-xylene (0.004–2.27 mg L−1), styrene (0.011–0.339 mg L−1), ethyl acetate (0.3–669.9 mg L−1), ethanol (16–38,742 mg L−1), methanol (66–3375 mg L−1), pyridine (0.077–99.7 mg L−1), acetylpyrazine (0.077–147 mg L−1), 2,3,5-trimethylpyrazine (0.008–96.8 mg L−1), and octamethylcyclotetrasiloxane (0.1–57.2 mg L−1). Benzene, toluene, ethylbenzene, m-xylene, p-xylene, and o-xylene coexisted in samples, which may have originated from the use of petrogenic hydrocarbons as an extraction solvent for flavor and nicotine from natural plants. The maximum detected concentrations of benzene, methanol, and ethanol in liquid samples were found in quantities higher than their authorized maximum limits as residual solvents in pharmaceutical products.