KIAA0101 mRNA overexpression in peripheral blood mononuclear cells acts as predictive marker for hepatic cancer

详细信息    查看全文

• 作者：Xiaomei Su (1)
  Tao Zhang (1)
  Peng Cheng (1)
  Yajie Zhu (1)
  Hua Li (1)
  Dong Li (1)
  Zhen Liu (1)
  Hui Gao (1)
  Zhenguo Zhao (1)
  Yu Zhao (1)
  Huanyi Liu (1)
  
• 关键词：KIAA0101 ; Overexpression ; Peripheral blood mononuclear cells ; Hepatic cancer ; Biomarker
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：March 2014
• 年：2014
• 卷：35
• 期：3
• 页码：2681-2686
• 全文大小：220 KB
• 参考文献：1. Kohles N, Nagel D, Jungst D, Durner J, Stieber P, Holdenrieder S. Prognostic relevance of oncological serum biomarkers in liver cancer patients undergoing transarterial undergoing transarterial chemoembolization therapy. Tumor Biol. 2012;33(1):33-0. CrossRef
  2. Jernal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69-0. CrossRef
  3. Siegel R, Ward E, Brawley O, Jernal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61(1):212-6. CrossRef
  4. EI-Serag HB. Hepatocellular carcinoma. N Eng J Med. 2011;365(12):1118-7. CrossRef
  5. Zhou J, Yu L, Gao X. Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma. Int J Clin Oncol. 2011;29(36):4781-. CrossRef
  6. Kung CI, Chen CY, Yang CC, Lin CY, Chen TH, Wang HS. The variant mRNA isofrom of human metastasis gene (CD44V) detected in the cell lines of human hepatocellular carcinoma. Biochem Mol Biol Int. 1994;32(2):233-.
  7. Dai L, Lei N, Liu M, Zhang JY. Autoantibodies to tumor-associated antigens as biomarker in human hepatocellular carcinoma (HCC). Exp Hematol Oncol. 2013;2(1):15. CrossRef
  8. Zhang X, Zhang Y, Li Y. Negative correlation of LIV-1 and E-cadherin expression in hepatocellular carcinoma cells. PLoS One. 2013;8(2):e56542. CrossRef
  9. Dong H, Tang J, Li LH, Ge J, Chen X, Ding J, et al. Serum carbohydrate antigen 19-9 as an indicator of liver metastasis in colorectal carcinoma cases. Asian Pac J Cancer Prev. 2013;14(2):909-3. CrossRef
  10. Mizutani K, Onda M, Asaka S, Akaishi J, Miyamoto S, Yoshida A, et al. Overexpressed in anaplastic thyroid carcinoma-1 (OEATC-1) as a novel gene responsible for anaplastic thyroid carcinoma. Cancer. 2005;103(9):1785-0. CrossRef
  11. Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, et al. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. Oncogene. 2004;23(46):7734-5. CrossRef
  12. Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, et al. p15 (PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene. 2001;20(4):484. CrossRef
  13. Simpson F, Lammerts BK, Buterfield N. The PCNA-associated factor KIAA0101/p15 binds the potential tumor suppressor product p33ING1b. Exp Cell Res. 2006;312(1):73-5. CrossRef
  14. Yuan RH, Jeng YM, Pan HW, Hu FC, Lai PL, Lee PH, et al. Overexpression of KIAA0101 predicts high stage, early tumor recurrence, and poor prognosis of hepatocellular carcinoma. Clin Cancer Res. 2007;13(18):5368-6. CrossRef
  15. Kais Z, Barsky SH, Mathsyaraia H, Zha A, Ransburgh DJ, He G, et al. KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res. 2011;9(8):1091-. CrossRef
  16. Hosokawa M, Takehara A, Matsuda K, Eguchi H, Ohigashi H, Ishikawa O, et al. Oncogenic role of KIAA0101 interacting with proliferating cell nuclear antigen in pancreatic cancer. Cancer Res. 2007;67(6):2568-6. CrossRef
  17. Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kail M. Overexpression of KIAA0101 predicts poor prognosis in primary lung cancer patients. Lung Cancer. 2012;75(1):110-. CrossRef
  18. Notterman DA, Alon U, Sierk AJ, Levine AJ. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 2001;61(7):3124-0.
  19. Liu L, Chen X, Xie S, Zhang C, Qiu Z, Zhu F. Variant 1 of KIAA0101, overexpression in hepatocellular carcinoma, prevents doxorubicin-induced apoptosis by inhibitng p53 activation. Hepatology. 2012;56(5):1760-. CrossRef
  20. Zhu K, Diao D, Dang C, Shi L, Wang J, Yan R, et al. Elevated KIAA0101 expression is a marker of recurrence in human gastric cancer. Cancer Sci. 2013;104(3):353-. CrossRef
  21. Zhang M, Huang B. The multi-differentiation potential of peripheral blood mononuclear cells. Stem Cell Ther. 2012;3(6):48. CrossRef
  22. Bielecki M, Kowal K, Lapinska A, Chyczewski L, Kowal-Bielecka O. Increased release of soluble CD163 by the peripheral blood mononuclear cells is associated with worse prognosis in patients with systemic sclerosis. Adv Med Sci. 2013;58(1):126-3. CrossRef
  23. Matsumura N, Zembutsu H, Yamaguchi K, Sasaki K, Tsuruma T, Nishidate T, et al. Identification of novel molecular markers for detection of gastric cancer cells in the peripheral blood circulation using genome-wide microarray analysis. Exp Ther Med. 2012;2(4):705-3.
  24. Terris B, Flejou JF, Ruszniewski P, Scoazec JY, Belghiti J, Potet F, et al. Increased expression of CD44v6 in endocrine pancreatic tumours but not in midgut carcinoid tumours. Clin Mol Pathol. 1996;49(4):203-. CrossRef
  25. Zhang Z, Shibahara K, Stillman B. PCNA connects DNA replication to epigenetic inheritance in yeast. Nature. 2000;408(6809):221-. CrossRef
  26. Wang X, Liang Y, Wang J, Wang M. Effect of NS-398, a cyclooxygenase-2 selective inhibitor, on the cytotoxicity of cytotoxic T lymphocytes to ovarian carcinoma cells. Tumor Biol. 2013;34(3):1517-2. CrossRef
  27. Zhu MC, Xu YJ, Zou X, Yan F. Down-regulation of HLA-A mRNA in peripheral blood mononuclear cell of colorectal cancer. Int J Color Dis. 2012;27(1):31-. CrossRef
  28. Ma GF, Miao Q, Zeng XQ, Luo TC, Ma LL, Liu YM, et al. Transforming growth factor-beta1 and -beta2 in gastric precancer and cancer and roles in tumor-cell interactions with peripheral blood mononuclear cells in vitro. PLoS One. 2013;8(1):e54249. CrossRef
  29. Wang J, Wang X, Chen Y, Wan M, Xiang Z, Wu X, et al. Immunization with a HSP65-HER2 fusion peptide selectively eliminates HER2 B16 melanoma cells in a xenograft tumor mouse model. Tumor Biol. 2013;34(1):193-01. CrossRef
  30. Bendardaf R, Algars A, Elzagheid A. Comparison of CD44 expression in primary tumors and metastases of colorectal cancer. Oncol Rep. 2006;16(5):741-.
  31. Selcukbiricik F, Bilici A, Tural D, Erdamar S, Soyluk O, Buyukunal E, et al. Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer? Tumor Biol. 2013;34(4):2233-. CrossRef
  
• 作者单位：Xiaomei Su (1)
  Tao Zhang (1)
  Peng Cheng (1)
  Yajie Zhu (1)
  Hua Li (1)
  Dong Li (1)
  Zhen Liu (1)
  Hui Gao (1)
  Zhenguo Zhao (1)
  Yu Zhao (1)
  Huanyi Liu (1)
  
  1. Department of Oncology, Chengdu Military General Hospital, No. 270 Rongdu Road, Chengdu City, Si Chuan Province, 610083, China
  
• ISSN：1423-0380

文摘

KIAA0101 always overexpresses in tumor tissues, which is also a marker of tumor recurrence. This study aims to explore whether overexpression of KIAA0101 mRNA in peripheral blood mononuclear cells (PBMCs) could act as a noninvasive and predictive biomarker of hepatic cancer. Real-time polymerase chain reaction (RT-PCR) was employed to detect KIAA0101 mRNA expression in PBMCs isolated from 93 hepatic cancer patients and 55 healthy individuals. The diagnostic sensitivity and specificity of KIAA0101 mRNA, CEA, and CD44V were analyzed and compared. A multivariate logistic regression analysis was utilized to analyze risk factors for overall survival of hepatic cancer patients. A concordance analysis was employed to compare the overexpression of KIAA0101 mRNA with clinicopathological diagnosis. All of the 93 hepatic cancer patients were followed up routinely at least 36?months or until death to analyze the 3-year overall survival rate. The results indicated that KIAA0101 mRNA expression was increased significantly in hepatic patients' PBMCs, when compared with that of healthy individuals (P-lt;-.05). Both the sensitivity and specificity of KIAA0101 mRNA in PBMCs were enhanced significantly compared with those of the CEA and CD44V biomarkers. The multivariate logistic regression analysis indicated that the KIAA0101 mRNA level and pTNM stage were significantly related with the overall survival of the hepatic patients. There was a better concordance between KIAA0101 mRNA overexpression and clinicopathological diagnosis for hepatic cancer (kappa--.914, P-lt;-.001). KIAA0101 mRNA overexpression in PBMCs decreased the 3-year survival rate significantly. In conclusion, overexpression of KIAA0101 mRNA in PBMCs could act as a predictive biomarker for hepatic cancer and has a better sensitivity and specificity.