Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis

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• 作者：Jianchun Gu (1)
  Leizhen Zheng (1)
  Yajie Wang (2)
  Meiling Zhu (1)
  Qin Wang (1)
  Xiaoping Li (1)
  
• 关键词：HER2 ; Human epidermal growth factor receptor ; Gastric cancer ; Prognosis ; Meta ; analysis
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：35
• 期：6
• 页码：5315-5321
• 全文大小：
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• 作者单位：Jianchun Gu (1)
  Leizhen Zheng (1)
  Yajie Wang (2)
  Meiling Zhu (1)
  Qin Wang (1)
  Xiaoping Li (1)
  
  1. Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China
  2. Department of Oncology, Changhai Hospital of the Second Military Medical University, Shanghai, 200433, China
  
• ISSN：1423-0380

文摘

The prognostic significance of HER2 expression in patients with gastric cancer remains controversial, partially due to the significant heterogeneity of the approaches and criteria used for HER2 assessment among different studies. We therefore conducted a meta-analysis enrolling only studies defining HER2 status by trastuzumab for gastric cancer (ToGA) criteria. Published studies investigating the association between HER2 expression and survival were identified. Only publications that defined HER2 expression using ToGA criteria were enrolled. Meta-analyses were performed by Revman 5.2. Pooled hazard ratio (HR) and its 95?% confidence interval (CI) were calculated to evaluate the risk of disease. A total of 11 studies were enrolled in meta-analyses. Pooled data of nine studies using univariate analysis showed that HER2 expression is not associated with overall survival (OS; pooled HR, 0.97; 95?% CI, 0.84-.12; P--.63), which are maintained in six studies of multivariate analysis (pooled HR, 1.01; 95?% CI, 0.75-.35; P--.95). The Q statistic test for nine studies of univariate analysis and for six studies of multivariate analysis showed no and low heterogeneity (I 2--2?% and P--.25; I 2--1?% and P--.13, respectively). Furthermore, pooled data of four studies without heterogeneity (I 2--?%, P--.74) showed that HER2 expression were not associated with relapse-free survival as well, with a pooled HR of 1.08 (95?% CI, 0.84-.37; P--.55) in patients with HER2 expression. In conclusion, this meta-analysis indicated that HER2 expression based on ToGA criteria is not related to the survival in patients with gastric cancer.