Development of a specific ^99mTc-MAG3-mAb-WF-AF-1 for noninvasive detection of Aspergillus fumigatus

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• 作者：Yajie Dang ; Xiao Li ; Mingrui Zheng…
• 关键词：Technetium ; 99m labeling ; Aspergillus fumigatus ; Noninvasive detection ; mAb ; WF ; AF ; 1
• 刊名：Journal of Radioanalytical and Nuclear Chemistry
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：310
• 期：1
• 页码：389-397
• 全文大小：756 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Nuclear Chemistry
  Physical Chemistry
  Nuclear Physics, Heavy Ions and Hadrons
  Diagnostic Radiology
  Inorganic Chemistry
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1588-2780
• 卷排序：310

文摘

Aspergillus species are ubiquitous fungi that can cause varieties of lung diseases. Early detection is critical for favorable outcomes. The feasibility of using a technetium-99m (99mTc)-labeled anti-Aspergillus monoclonal antibody (WF-AF-1) targeting the Aspergillus cell wall for the early detection of Aspergillusfumigatus in the lung was evaluated. In vitro binding study showed 99mTc-WF-AF-1 preferentially bound to A. fumigatus. Biodistribution and scintigraphy showed significant accumulation of radioactivity in A. fumigatus conidia-instilled lungs. This study demonstrated that 99mTc-WF-AF-1 directly targeting A. fumigatus may be valuable for early, noninvasive detection, and provides a referable strategy for the detection of other microorganisms.