Tocilizumab dramatically ameliorated life-threatening diarrhea due to secondary amyloidosis associated with rheumatoid arthritis
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- 作者：Hiroe Sato ; Takehito Sakai ; Toshiaki Sugaya ; Yasuhiro Otaki ; Kana Aoki ; Katsushi Ishii ; Hidehiro Horizono ; Hiroshi Otani ; Asami Abe and Noboru Yamada ; et al.
- 关键词：Diarrhea ; Rheumatoid arthritis ; Secondary amyloidosis ; Tocilizumab
- 刊名：Clinical Rheumatology
- 出版年：2009
- 出版时间：September, 2009
- 年：2009
- 卷：28
- 期：9
- 页码：1113-1116
- 全文大小：180.1 KB
文摘
Severe diarrhea improved dramatically with administration of the humanized anti-interleukin-6 receptor antibody tocilizumab (TCZ) in a patient with secondary reactive amyloidosis, which was associated with rheumatoid arthritis (RA). A 53-year-old woman with RA went into hypovolemic shock because of severe watery diarrhea associated with gastrointestinal amyloidosis. The high-dose prednisolone therapy and glucocorticoid pulse therapy did not improve her intractable diarrhea. After TCZ administration, the life-threatening diarrhea lessened in about 6 h, and her vital signs became stable the next day. Perforation of the small intestine, however, occurred 2 days after TCZ administration. Whether TCZ could have been involved in the perforation in such a short time is unknown. Surgery was successful, and the patient recovered. TCZ may work immediately in diarrhea associated with secondary amyloidosis.