Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis

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• 作者：Yutaka Harita (1)
  Kiyonobu Ishizuka (2)
  Atsushi Tanego (3)
  Noriko Sugawara (2)
  Hiroko Chikamoto (2)
  Yuko Akioka (2)
  Haruko Tsurumi (1)
  Kenichiro Miura (1)
  Yoshimitsu Gotoh (4)
  Makoto Tsujita (5)
  Takayuki Yamamoto (5)
  Keiji Horike (5)
  Asami Takeda (5)
  Akira Oka (1)
  Takashi Igarashi (1)
  Motoshi Hattori (2)
  
• 关键词：Soluble urokinase receptor ; Focal segmental glomerulosclerosis ; Post ; transplant recurrence
• 刊名：Pediatric Nephrology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：29
• 期：9
• 页码：1553-1560
• 全文大小：676 KB
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• 作者单位：Yutaka Harita (1)
  Kiyonobu Ishizuka (2)
  Atsushi Tanego (3)
  Noriko Sugawara (2)
  Hiroko Chikamoto (2)
  Yuko Akioka (2)
  Haruko Tsurumi (1)
  Kenichiro Miura (1)
  Yoshimitsu Gotoh (4)
  Makoto Tsujita (5)
  Takayuki Yamamoto (5)
  Keiji Horike (5)
  Asami Takeda (5)
  Akira Oka (1)
  Takashi Igarashi (1)
  Motoshi Hattori (2)
  
  1. Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
  2. Department of Pediatric Nephrology, Tokyo Women鈥檚 Medical University, Tokyo, Japan
  3. Division of Biochemistry, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan
  4. Department of Pediatric Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan
  5. Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Japan
  
• ISSN：1432-198X

文摘

Background Circulating factor(s) has been thought to be the underlying cause of focal segmental glomerulosclerosis (FSGS), and recent studies foster this idea by demonstrating increased soluble urokinase receptor (suPAR) levels in the serum of FSGS patients. Methods To explore the possible contribution of suPAR in FSGS pathogenesis, we analyzed serum suPAR levels in 17 patients with FSGS and compared them with those in patients with steroid-sensitive nephrotic syndrome, chronic glomerulonephritis, or non-glomerular kidney diseases. Results Serum suPAR levels in patients with FSGS were higher than those in patients with steroid-sensitive nephrotic syndrome or chronic glomerulonephritis, but not higher than those in patients with non-glomerular kidney diseases. suPAR levels negatively correlate with estimated glomerular filtration rate and were decreased after renal transplantation in patients with FSGS as well as in those with non-glomerular kidney diseases. Furthermore, 6 FSGS patients with post-transplant recurrence demonstrated that suPAR levels were not high during the recurrence. Conclusions Based on our results, elevated suPAR levels in FSGS patients were attributed mainly to decreased glomerular filtration. These data warrant further analysis for involvement of possible circulating factor(s) in FSGS pathogenesis.