L-Arginine supplementation in mice enhances NO production in spleen cells and inhibits Plasmodium yoelii transmission in mosquitoes
详细信息 查看全文
- 作者：Li Zheng ; Yanyan Pan ; Yonghui Feng ; Liwang Cui ; Yaming Cao
- 关键词：Plasmodium yoelii ; L ; Arginine ; Immune regulation ; Blood stage ; Mosquito
- 刊名：Parasites & Vectors
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：1
- 全文大小：802 KB
- 刊物主题：Parasitology; Infectious Diseases; Tropical Medicine; Entomology;
- 出版者：BioMed Central
- ISSN：1756-3305
文摘
Background The life cycle of Plasmodium is complex, requiring invasion of two different hosts, humans and mosquitoes. In humans, initiation of an effective Th1 response during early infection is critical for the control of parasite multiplication. In mosquitoes, inhibition of the development of sexual-stage parasites interrupts the parasite transmission. In this study, we aim to investigate whether dietary supplementation of L-arginine (L-Arg) in mice affects Plasmodium yoelii 17XL (Py17XL) transmission in mosquitoes.