Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects
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- 作者：Yanfeng Liu (1) (2) (3)
Hyun-dong Shin (4)
Jianghua Li (1) (2) (3)
Long Liu (1) (2) (3) - 关键词：System metabolic engineering ; Modular pathway engineering ; Synthetic biology ; Genome ; scale metabolic model ; Spatial engineering
- 刊名：Applied Microbiology and Biotechnology
- 出版年：2015
- 出版时间：February 2015
- 年：2015
- 卷：99
- 期：3
- 页码：1109-1118
- 全文大小：888 KB
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Hyun-dong Shin (4)
Jianghua Li (1) (2) (3)
Long Liu (1) (2) (3)
1. Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China
2. Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi, 214122, China
3. Synergetic Innovation Center of Food Safety and Nutrition, Wuxi, 214122, China
4. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, 30332, USA - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Biotechnology
Microbiology
Microbial Genetics and Genomics - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0614
文摘
Metabolic engineering facilitates the rational development of recombinant bacterial strains for metabolite overproduction. Building on enormous advances in system biology and synthetic biology, novel strategies have been established for multivariate optimization of metabolic networks in ensemble, spatial, and dynamic manners such as modular pathway engineering, compartmentalization metabolic engineering, and metabolic engineering guided by genome-scale metabolic models, in vitro reconstitution, and systems and synthetic biology. Herein, we summarize recent advances in novel metabolic engineering strategies. Combined with advancing kinetic models and synthetic biology tools, more efficient new strategies for improving cellular properties can be established and applied for industrially important biochemical production.