The integration of weighted human gene association networks based on link prediction
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- 作者：Jian Yang ; Tinghong Yang ; Duzhi Wu ; Limei Lin ; Fan Yang ; Jing Zhao
- 关键词：Gene association network ; Weighted network ; Link prediction ; Network integration
- 刊名：BMC Systems Biology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：11
- 期：1
- 全文大小：3216KB
- 刊物主题：Bioinformatics; Systems Biology; Simulation and Modeling; Computational Biology/Bioinformatics; Physiological, Cellular and Medical Topics; Algorithms;
- 出版者：BioMed Central
- ISSN：1752-0509
- 卷排序：11
文摘
BackgroundPhysical and functional interplays between genes or proteins have important biological meaning for cellular functions. Some efforts have been made to construct weighted gene association meta-networks by integrating multiple biological resources, where the weight indicates the confidence of the interaction. However, it is found that these existing human gene association networks share only quite limited overlapped interactions, suggesting their incompleteness and noise.